Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.

• Project/Area Number: 26462226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Funakoshi Tadanao 北海道大学, 大学病院, 講師 (10528334)
• Co-Investigator(Kenkyū-buntansha): 東藤 正浩 北海道大学, 工学研究院, 准教授 (10314402) ; 岩崎 倫政 北海道大学, 医学研究科, 教授 (30322803) ; 小野寺 智洋 北海道大学, 大学病院, 講師 (70547174)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: リハビリテーション / 理学療法 / 四肢機能再建学 / 関節軟骨

Outline of Final Research Achievements

Effect of hyaluronic acid (HA) for osteoarthritis is still controversial. We examined the histopathological changes and the friction coefficient in osteoarthritic knee joint after different molecular weight HA injection (low molecular weight HA, 0.8x106 Da or Ultra-high molecular weight, 6x106 Da) using a rabbit osteoarthritis model. Macroscopic findings showed that severe damaged cartilage was observed in 10% of Ultra-high molecular weight HA and 30% of low molecular weight HA and NS. The histological score and the friction coefficient value of Ultra-high molecular weight HA group were significantly lower than those of the control group (P < 0.05). Ultra-high molecular weight HA has potential chondroprotective effects and superior fiction coefficient. These factors would contribute to prevent progression of osteoarthritis. Intrajoint alteration of molecular weight HA should be clarified in future study.

Research Products

• [Journal Article] Viability of Cells From Displaced Fragments of the Elbow Osteochondritis Dissecans: Alternative Source of Autologous Chondrocyte Implantation. (2017)
  • Author(s): Kameda Y, Funakoshi T, Takeuchi S, Sugawara K, Iwasaki N.
  • Journal Title: Arthroscopy Volume: 33 Issue: 2 Pages: 291-296
  • DOI: 10.1016/j.arthro.2016.09.005
  • Acknowledgement Compliant
• [Journal Article] Alteration of Stress Distribution Patterns in the Symptomatic Valgus Instability of the Elbow in Baseball Players Using Computed Tomography Osteoabsorptiometry. (2016)
  • Author(s): Funakoshi T, Furushima K, Momma D, Endo K, Abe Y, Itoh Y, Fujisaki K, Tadanao S, Iwasaki N
  • Journal Title: Am J Sports Med Volume: 44 Issue: 4 Pages: 989-994
  • DOI: 10.1177/0363546515624916
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Viability of Cells From Displaced Fragments of the Elbow Osteochondritis Dissecans: Alternative Source of Autologous Chondrocyte Implantation. (2017)
  • Author(s): Funakoshi T, Kameda Y, Takeuchi S, Sugawara K, Iwasaki N.
  • Organizer: Orthopaedic Reseach Society
  • Place of Presentation: San Diego（USA）
  • Year and Date: 2017-03-19
• [Presentation] 超高分子量ヒアルロン酸が関節軟骨マトリクスに与える影響 (2016)
  • Author(s): 船越忠直、Elmorsy S、岩崎倫政
  • Organizer: 第65回東日本整形災害外科学会
  • Place of Presentation: ザ・プリンス箱根芦ノ湖（神奈川県足柄下郡箱根町）
  • Year and Date: 2016-09-22
• [Presentation] 上腕骨小頭離断性骨軟骨炎に対する骨軟骨柱移植術 (2016)
  • Author(s): 船越忠直、松井雄一郎、河村太介、亀田裕亮、岩崎倫政
  • Organizer: 第59回日本手の外科学会
  • Place of Presentation: 広島国際会議場（広島県広島市）
  • Year and Date: 2016-04-21
• [Presentation] The 4-dimensional computed tomographic scanner allows dynamic visualization and measurement of asymptomatic glenohumeral Joint Motion (2015)
  • Author(s): 船越忠直、岩崎倫政
  • Organizer: 第88回日本整形外科学術集会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-05-21
• [Presentation] Chondroprotective Effects of Ultra-High Molecular Weight Hyaluronic acid in a Rabbit Knee Osteoarthritis Model (2014)
  • Author(s): Elmorsy S, Funakoshi T, Iwasaki N, Tsukuda Y, Sasazawa F, Todoh M, Tadano S, Minami A
  • Organizer: 第87回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル（神戸市）
  • Year and Date: 2014-05-22 – 2014-05-25