Functional role of Syndecan-4 in the process of osteochondral repair
Project/Area Number |
26462257
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
岩崎 倫政 北海道大学, 医学研究科, 教授 (30322803)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 整形外科 / 軟骨損傷 / 軟骨再生 / 骨軟骨修復 / 動物モデル / 軟骨修復 / シンデカン4 |
Outline of Final Research Achievements |
We successfully developed novel osteochondral repair model by using young C57Bl/6 mice(Matsuoka M, Onodera T et al., Tissue Eng. 2015)。This novel animal model made us to clarify the cartilage repair mechanisms in glycosphingolipid depletion mice(Matsuoka M, Onodera T et al., Sci Rep. 2017)。In addition, we applied this animal model to Syndecan-4 knockout mice. Surprisingly, osteochondral repair in Syndecan-4 knockout mice is enhanced compare with wildtype mice.
|
Report
(4 results)
Research Products
(4 results)
-
[Journal Article] Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice2017
Author(s)
Matsuoka Masatake, Onodera Tomohiro, Homan Kentarou, Sasazawa Fumio, Furukawa Junichi, Momma Daisuke, Baba Rikiya, Hontani Kazutoshi, Joutoku Zenta, Matsubara Shinji, Yamashita Tadashi, Iwasaki Norimasa.
-
Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 43729-43729
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-