Development of diagnosis and elucidation of the onset mechanism for hypermobility type of Ehlers-Danlos syndrome
| Project/Area Number |
26462296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エーラス・ダンロス症候群 / テネイシンX / 関節可動亢進 / 過剰運動症候群 / プロテオミクス解析 / 質量分析 / フィブリン／コラーゲンゲル / ESI-TSQ質量分析 / 発現差異プロテオミクス解析 / MALDI-TOF/TOF質量分析 / 血清濃度測定 / ESI-TSQ質量分析計 |
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| Outline of Final Research Achievements |
Hypermobility type of Ehlers-Danlos syndrome (EDS) is a heritable connective tissue disorder characterized by joint hypermobility. We developed a method for quantification of serum TNX, one of the causative genes of hypermobility type of EDS, using nano-liquid chromatography tandem mass spectrometry. It was revealed that serum concentrations of TNX of healthy individuals were quantified as an average of 144 ng/ml. Furthermore, in order to identify potential serum biomarkers for hypermobility type of EDS, we examined proteins with differential levels in sera from the patients by proteomic analyses. We identified 6 proteins involved in the complement system as increased proteins in sera from the patients.
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Report
(4 results)
Research Products
(41 results)
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[Presentation] Role of tenascin-X in extracellular matrix2016
Author(s)
Ken-ichi Matsumoto
Organizer
The extracellular matrix and beyond”in Symposium in honor of Ruth Chiquet-Ehrismann
Place of Presentation
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Year and Date
2016-04-22
Related Report
Int'l Joint Research / Invited
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