| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Hypermobility type of Ehlers-Danlos syndrome (EDS) is a heritable connective tissue disorder characterized by joint hypermobility. We developed a method for quantification of serum TNX, one of the causative genes of hypermobility type of EDS, using nano-liquid chromatography tandem mass spectrometry. It was revealed that serum concentrations of TNX of healthy individuals were quantified as an average of 144 ng/ml. Furthermore, in order to identify potential serum biomarkers for hypermobility type of EDS, we examined proteins with differential levels in sera from the patients by proteomic analyses. We identified 6 proteins involved in the complement system as increased proteins in sera from the patients.
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