| Project/Area Number |
26462316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 悠太 和歌山県立医科大学, 医学部, 講師 (00580672)
一瀬 雅夫 和歌山県立医科大学, 医学部, 教授 (50143425)
上山 敬司 和歌山県立医科大学, 医学部, 教授 (50264875)
上田 和樹 和歌山県立医科大学, 医学部, 博士研究員 (50405437)
鶴尾 吉宏 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (90207449)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 胃切除 / 骨代謝異常 / 炎症 / 胃切除動物 / マイクロアレイ / 直腸 / リンパ球浸潤 / LC-MS / リンパ球 / 浸潤 / 骨代謝 / 組織化学 / 遺伝子解析 / 臓器連関 |
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| Outline of Final Research Achievements |
We reported the abnormality of bone metabolism in gastrectomized rats. However, the effects of gastrectomy in multiple organs had not been clear. We examined the effect of gastrectomy on rat livers with analysis of gene expression, biochemistry, and histological changes.
Microarray analysis identified 573 differential expressed genes in gastrectomized rat liver, and pathway analysis indicated statistically relationship between these genes and steroid signaling and lipid metabolism. In gastrectomized rats, serum ALT was increased, and small droplets were observed in hepatocyte. Furthermore, lethal events were significantly happened in gastrectomy rats.
The case reports about liver dysfunction after gastrectomy have been reported, this study may explain the mechanisms of these cases.
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