Cardioprotective effects of phosphodiesterase-3 inhibitor in hyperglycemic swine
| Project/Area Number |
26462338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
HARA Tetsuya 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50304952)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 虚血再灌流傷害 / 気絶心筋 / オルプリノン / 高血糖 / コンディショニング / ホスホジエステラーゼ阻害薬 |
|---|
| Outline of Final Research Achievements |
Olprinone, phosphodiesterase-3 inhibitor, improves the contractile functional recovery against stunned myocardium in hyperglycemic swine. Activation of phosphatidylinositol-3 kinase/Akt and protein kinase A would be involved in this cardioprotective mechanism.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] 麻酔と循環管理2015
Author(s)
原哲也
Organizer
日本臨床麻酔学会
Place of Presentation
パシフィコ横浜（神奈川県・横浜市）
Year and Date
2015-10-21
Related Report
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