| Project/Area Number |
26462339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
INADOMI Chiaki 長崎大学, 病院(医学系), 講師 (20508444)
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| Co-Investigator(Kenkyū-buntansha) |
李 桃生 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
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| Research Collaborator |
YANO Rintaro 長崎大学, 病院(医学系), 助教
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 循環・高血圧 / 虚血再灌流障害 / 高濃度酸素 / 幹細胞 / 虚血再還流障害 |
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| Outline of Final Research Achievements |
It is well known that ischemic preconditioning induces stem cell mobilization and protects against ischemic/reperfusion (I/R) injury. In this study, we investigated the effect of transient oxygenation on stem cell mobilization and I/R injury of the heart in mice. The number of c-kit+ stem/progenitor cells in peripheral blood was significantly increased at 1 or 24 hours after oxygenation for 5 minutes. Oxygenation for 5 or 20 minutes did not significantly change the SDF-1α level measured in plasma. Oxygenation for 5 minutes did not significantly alter the fibrotic area or cell apoptosis. Oxygenation for 5 minutes increased the number of c-kit+ cells in hearts damaged by I/R injury. However, this difference was not significant between groups. Although transient oxygenation induces stem cell mobilization, it does not appear to protect against I/R injury of the heart in mice.
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