Voxel based morphometry (VBM), brain imaging of a multifaceted chronic pain evaluation.

• Project/Area Number: 26462381
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Fukui Sei 滋賀医科大学, 医学部, 講師 (80303783)
• Research Collaborator: TANAKA Sachiko ; IWASHITA Narihito ; YOSHIMURA Masaharu ; MIYATA Katsunori ; ITOH Akira
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Voxel based morphometry / 慢性疼痛 / 灰白質体積 / 灰白質密度 / 扁桃体 / 脳形態変化 / voxel based morphometry / Voxel-based morphometry

Outline of Final Research Achievements

Voxel based morphometry (VBM) is a morphological brain imaging method. VBM can statistically detect morphological changes of the brain and measure gray matter volume. We evaluated brain morphological change using voxel-based morphometry on ninety two patients who suffer from chronic pain. The gray matter volume was most decreased in amygdala in chronic pain patients. Left amygdala showed a statistically significant decrease in gray matter volume more than right amygdala. Furthermore, we searched morphologi cal change after 4 months treatment about 3 patients who had gray matter decrease in .amygdala.　Our results suggest that gray matter decrease in amygdala may normalize by treatment.
Amygdala is associated with negative emotions and dysfunction of amygdala influences chronic pain as expression of pain behavior. Examining changes in gray matter volume of the brain using VBM may be one method of a multifaceted approach to chronic pain.

Research Products

• [Journal Article] Proton magnetic resonance spectroscopy (1H-MRS) assessment of metabolite status of the anterior cingulate cortex in chronic pain patients and healthy controls. (2017)
  • Author(s): Takahiro Ito,Sachiko Tanaka-Mizuno,Narihito Iwashita,Ikuo Tooyama,Akihiko Shiino,Katsuyuki Miura, Sei Fukui
  • Journal Title: Journal of Pain Research Volume: 10 Pages: 287-293
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ペインクリニックにおける画像診断：慢性疼痛における脳の形態変化-VBMを中心に- (2016)
  • Author(s): 福井 聖、岩下成人、新田一仁
  • Journal Title: ペインクリニック Volume: 37
  • Peer Reviewed
• [Journal Article] 脳の形態学的変化から考える慢性痛と情動 (2016)
  • Author(s): 福井 聖、亀田 拓哉、富永 亮司
  • Journal Title: ペインクリニック Volume: 37 Pages: 1-9
  • Peer Reviewed
• [Journal Article] インクリニックにおける画像診断：脳機能画像法の基本と疼痛関連領域の評価 (2016)
  • Author(s): 岩下成人、福井 聖、新田一仁
  • Journal Title: ペインクリニック Volume: 37
  • Peer Reviewed
• [Journal Article] 脳画像診断法ー局所脳機能からネットワークへ (2016)
  • Author(s): 岩下成人、福井 聖、新田一仁
  • Journal Title: ペインクリニック Volume: 37 Pages: 505-510
  • Peer Reviewed
• [Journal Article] 慢性疼痛における脳の形態変化-VBMを中心に- (2016)
  • Author(s): 福井 聖、岩下成人、新田一仁
  • Journal Title: ペインクリニック Volume: 37 Pages: 87-100
  • Peer Reviewed
• [Journal Article] 「慢性痛における脳の変化」脳形態変化を中心に (2015)
  • Author(s): 福井 聖
  • Journal Title: ペインクリニック Volume: 36 Pages: 1495-1508
  • Peer Reviewed
• [Journal Article] 慢性腰痛と脳の形態変化 (2015)
  • Author(s): 福井 聖、新田一仁
  • Journal Title: Locomotive pain Frontier Volume: 4 Pages: 24-31
  • NAID: 40020640527
  • Peer Reviewed
• [Journal Article] Voxel–based morphometry を用いた慢性腰痛患者の扁桃体形態変化の評価の試み (2015)
  • Author(s): 新田一仁、福井聖、岩下成人、他
  • Journal Title: Pain Reaearch Volume: 30 Pages: 7-15
  • NAID: 130005061787
  • Peer Reviewed / Open Access
• [Journal Article] Voxel–based morphometry を用いた慢性腰痛患者の形態学的脳画像評価と治療後の脳形態変化 (2014)
  • Author(s): 新田一仁、福井聖、岩下成人、他
  • Journal Title: 日本運動器疼痛学会誌 Volume: 6 Pages: 124-131
  • NAID: 40020196651
  • Peer Reviewed / Open Access
• [Presentation] Voxel-based Morphometric Values of the Brain in Patients with CRPS, fibromyalgia and cervico-omo-brachial syndrome. (2016)
  • Author(s): Kazuhito. Nitta, Sei. Fukui, Takuya Kameda, Ryoji Tominaga, Miho Sekiguchi, Narihito. Iwashita, Hirotoshi Kitagawa, Shinichi Konno, Sachiko Tanaka
  • Organizer: 16th World Congress on Pain,
  • Place of Presentation: Yokohama
  • Int'l Joint Research
• [Presentation] Correlation between Voxel-based Morphometric Values of the Brain and Pain Assessment Scale Scores in Patients with Chronic Pain. (2016)
  • Author(s): Sei. Fukui, Takuya Kameda, Ryoji Tominaga, Miho Sekiguchi, Kazuhito. Nitta, Narihito. Iwashita, Hirotoshi Kitagawa, Shinichi Konno, Sachiko Tanaka.
  • Organizer: 16th World Congress on Pain,
  • Place of Presentation: Yokohama
  • Int'l Joint Research
• [Presentation] Voxel-based brain morphometry and a screening tool for detecting cognitive impairment in chronic pain patients (2016)
  • Author(s): Yuma Snoda, Sei Fukui, Kazuhito Nitta, Narihito Iwashita, Tomonori Adachi, Yasuyuki Hiraiwa, Masato Kugo, Taku Kawasaki
  • Organizer: 16th World Congress on Pain,
  • Place of Presentation: Yokohama
  • Int'l Joint Research
• [Presentation] Voxel-based Morphometric Values of the Brain in Patients with chronic low back pain. (2016)
  • Author(s): Ryoji Tominaga , Sei. Fukui , Takuya Kameda, Miho Sekiguchi , Narihito. Iwashita , Kazuki Ito , Sachiko Tanaka , Shin-ichi Konno.
  • Organizer: 16th World Congress on Pain,
  • Place of Presentation: Yokohama
  • Int'l Joint Research
• [Presentation] 脳の形態学的変化から考える慢性痛と情動 (2016)
  • Author(s): 福井 聖
  • Organizer: 第9回日本運動器疼痛学会
  • Place of Presentation: 東京、御茶ノ水
• [Presentation] 非特異的慢性腰痛患者における局所脳灰白質体積変化 (2015)
  • Author(s): 新田一仁、福井聖、岩下成人、北川裕利
  • Organizer: 日本運動器疼痛学会第８回大会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2015-12-12
• [Presentation] Correlation between Voxel-based Morphometric Values of the Brain and Pain Assessment Scale Scores in Patients with Chronic Low Back Pain. (2015)
  • Author(s): Sei. Fukui, Narihito. Iwashita, Kazuhito. Nitta, Noriko Takebayashi, Hirotoshi Kitagawa
  • Organizer: 9th Congress of the European Pain Federation (EFIC)
  • Place of Presentation: Wien,Austria
  • Year and Date: 2015-09-03
  • Int'l Joint Research
• [Presentation] 慢性腰痛患者における灰白質形態評価：情動と脳灰白質体積の相関 (2015)
  • Author(s): 新田一仁、福井聖、岩下成人、北川裕利
  • Organizer: 日本ペインクリニック学会第49回大会
  • Place of Presentation: グランフロント大阪ナレッジキャピタル、大阪
  • Year and Date: 2015-07-25
• [Presentation] Correlation between Voxel-based Morphometric Values of the Brain and Pain Assessment Scale Scores in Patients with Chronic Low Back Pain (2014)
  • Author(s): Kazuhito. Nitta, Sei Fukui, Narihito Iwashita, et al.
  • Organizer: 1st CiNet Conference 'New Directions in Pain Neuroscience
  • Place of Presentation: Osaka Univerty1st CiNet
  • Year and Date: 2014-12-03
• [Presentation] Voxel-based morphometrｙを用いた脳形態評価と破局化思考 (2014)
  • Author(s): 新田一仁、福井 聖、岩下成人、他
  • Organizer: 第７回日本運動器疼痛学会
  • Place of Presentation: 宇部ANAホテル、山口
  • Year and Date: 2014-10-25
• [Presentation] 慢性腰痛患者におけるVoxel-based morphometrｙを用いた脳形態と疼痛問診票の相関評価 (2014)
  • Author(s): 新田一仁、福井 聖、岩下成人、他
  • Organizer: 日本ペインクリニック学会第48回大会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 2014-07-25
• [Presentation] Voxel-based morphometryを用いた慢性腰痛患者の扁桃体形態変化の評価の試み (2014)
  • Author(s): 新田一仁、福井 聖、岩下成人、他
  • Organizer: 第36回日本疼痛学会
  • Place of Presentation: KKRホテル大阪、大阪
  • Year and Date: 2014-06-21
• [Book] 痛みのバイオマーカーとしての機能的脳画像診断法 (2016)
  • Author(s): 福井 聖、新田一仁
  • Total Pages: 7
  • Publisher: 真興交易
• [Book] 痛みのバイオマーカーとしての機能的脳画像診断法 (2016)
  • Author(s): 福井 聖、岩下成人
  • Total Pages: 5
  • Publisher: 真興交易
• [Book] メカニズムから読み解く痛みの臨床テキスト (2015)
  • Author(s): 福井 聖（弥己郎）、新田一仁
  • Publisher: 南江堂
• [Book] ペインクリニシャンのための新キーワード136 (2014)
  • Author(s): 福井 聖（弥己郎）
  • Publisher: 真興交易