Endolymph control system of the endolympatic sac and the stria vascularis
| Project/Area Number |
26462559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内耳 / 内リンパ嚢 / イオン輸送 / イメージング / イオンイメージング / 血管条 / 減塩治療 / アルドステロン / メニエール病 / RT-PCR |
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| Outline of Final Research Achievements |
A low-salt diet was an effective treatment for patients with Meniere’s disease. This treatment will have a greater effect, when sodium intake is reduced to less than 3 g/day. A low-salt diet may induce an increase in the plasma aldosterone concentration that can activate ion transport and absorbing endolymph in the endolymphatic sac.
We also detected the expression of tricellulin, which is involved in controlling intracellular ion transport, in endolymphatic sac epithelia. Furthermore, we developed a new 3D imaging system for the endolymphatic sac.
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Report
(4 results)
Research Products
(14 results)
