Examination of the molecular target treatment for CD70 in the nasal NK/T cell lymphoma
| Project/Area Number |
26462576
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Kishibe Kan 旭川医科大学, 医学部, 講師 (80447101)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 鼻性NK/T細胞リンパ腫 / 悪性リンパ腫 / CD70 / EBV / 抗体療法 / NK/T細胞リンパ腫 |
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| Outline of Final Research Achievements |
I investigated a murine xenograft in vivo model, using NOD/Shi-scid/IL-2Rγ null (NOG) mice inoculated subcutaneously with SNK-6 that was established from primary site of the nasal NK/T cell lymphoma (NNKTL). Tumor formation at the inoculated site was detectable in all of the NOG mice. Histologically, the tumor was formed by atypical lymphoid cells that were positive for EBER and CD56. These characteristics were similar to those of the malignant cells that form the tumor tissue of NNKTL patients. Immunohistological staining was performed to analyze CD70 expression in formalin-fixed, paraffin-embedded tissue sections prepared from the subcutaneous tumor. These neoplastic cells clearly expressed CD70. These results suggest that not only cultured SNK-6 cells but also the SNK-6 tumor in the in vivo xenograft model could express CD70.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy2017
Author(s)
Toshihiro Nagato, Takayuki Ohkuri, Kenzo Ohara, Yui Hirata, Kan Kishibe, Yuki Komabayashi, Seigo Ueda, Miki Takahara, Takumi Kumai, Kei Ishibashi, Akemi Kosaka, Naoko Aoki, Kensuke Oikawa, Yuji Uno, Naoko Akiyama, Masatoshi Sado, Hidehiro Takei, Esteban Celis, Yasuaki Harabuchi, Hiroya Kobayashi
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Journal Title
Cancer Immunol Immunother
Volume: 印刷中
Issue: 7
Pages: 877-890
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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