• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The effects of olfactory sensory inputs on maturation process of newly generated olfactory sensory neurons

Research Project

Project/Area Number 26462577
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

Kikuta Shu  東京大学, 医学部附属病院, 助教 (00555865)

Co-Investigator(Kenkyū-buntansha) 近藤 健二  東京大学, 東京大学・医学部附属病院, 准教授 (40334370)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Keywords耳鼻咽喉科 / 嗅覚障害 / 嗅神経 / 嗅覚 / 感覚入力 / 嗅上皮障害 / 再生
Outline of Final Research Achievements

We examined whether olfactory sensory deprivation affected the dynamic incorporation of newly generated OSNs 3, 7, 14, and 28 days post-injury in adult mice. No significant differences in the numbers of olfactory marker protein (OMP)-positive mature OSNs or apoptotic OSNs were observed between the deprived and non-deprived sides 0-7 days post-injury. However, between days 7 and 28, the sensory deprived side showed markedly fewer OSNs and mature OSNs but more apoptotic OSNs than the non-deprived side. Intrinsic functional imaging of the dorsal surface of the olfactory bulb at day 28 revealed that responses to odor stimulation were weaker in the deprived side compared with those in the non-deprived side. These results indicate that in the adult OE sensory deprivation disrupts compensatory OSN regeneration following injury and that newly generated OSNs have a critical time window for sensory input-dependent survival 7-14 days post-injury.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.2016

    • Author(s)
      Kikuta S, Matsumoto Y, Kuboki A, Nakayama T, Asaka D, Otori N, Kojima H, Sakamoto T, Akinori K, Kanaya K, Ueha R, Kagoya R, Nishijima H, Toma-Hirano M, Kikkawa Y, Kondo K, Tsunoda K, Miyaji T, Yamaguchi T, Kataoka K, Mori K, Yamasoba T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 35361-35361

    • DOI

      10.1038/srep35361

    • NAID

      130006708720

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensory deprivation disrupts homeostatic regeneration of newly generated olfactory sensory neurons after injury in adult mice.2015

    • Author(s)
      Kikuta S, Sakamoto T, Nagayama S, Kanaya K, Kinoshita M, Kondo K, Tsunoda K, Mori K, Yamasoba T.
    • Journal Title

      J Neurosci.

      Volume: 35 Issue: 6 Pages: 2657-2673

    • DOI

      10.1523/jneurosci.2484-14.2015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 異嗅症はなぜ起きるのか?2014

    • Author(s)
      菊田 周
    • Journal Title

      JOHNS

      Volume: 30 Pages: 881-884

    • Related Report
      2014 Research-status Report
  • [Presentation] Eosinophilic Cationic Proteinによる嗅細胞障害に対するインスリン点鼻投与の予防効果2016

    • Author(s)
      菊田 周、久保木章仁、坂本幸士、金谷香織、上羽瑠美、西嶌大宣、近藤健二、山岨達也
    • Organizer
      日本鼻科学会総会・学術講演会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] インスリン点鼻投与による嗅細胞の細胞死抑制効果2016

    • Author(s)
      菊田 周、久保木章仁、松本 有、坂本幸士、金谷香織、和田翠、籠谷領二、西嶌大宣、平野真希子、吉川弥生、近藤健二、山岨達也
    • Organizer
      日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      名古屋市
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] アリナミンテストにおける新たな意義2015

    • Author(s)
      菊田 周
    • Organizer
      第54回日本鼻科学会 総会・学術講演会
    • Place of Presentation
      広島国際会議場(広島市)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 嗅上皮の恒常性維持におけるインスリンシグナルの関与2015

    • Author(s)
      久保木章仁、菊田 周、坂本幸士、松本 有、浅香大也、飯村慈朗、小島博己、鴻 信義、山岨達也
    • Organizer
      第116回日本耳鼻咽喉科学会 総会・学術講演会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
  • [Presentation] アリナミンテストの新たな意義2014

    • Author(s)
      菊田周、松本有、坂本幸士、岩村均、西嶌大宣、平野真希子、近藤健二、山岨達也
    • Organizer
      第53回日本鼻科学会総会
    • Place of Presentation
      コングレコンベンションセンター(大阪市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] アリナミンテストの結果に対する病態に基づいた新たな解釈2014

    • Author(s)
      菊田周、松本有、坂本幸士、近藤健二、上羽瑠美、岩村均、鈴川佳吾、平野真希子、山岨達也
    • Organizer
      第115回日本耳鼻咽喉科学会総会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡市)
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 嗅覚障害治療剤2016

    • Inventor(s)
      菊田周
    • Industrial Property Rights Holder
      菊田周
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-028504
    • Filing Date
      2016-02-18
    • Acquisition Date
      2016-11-11
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi