| Project/Area Number |
26462642
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杉本 貴子 宮崎大学, 医学部, 助教 (40381074)
直井 信久 宮崎大学, 医学部, 教授 (50211412)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 副腎皮質ステロイド / L-アルギニン / rNAION / 角膜電気刺激 / 単離短後毛様動脈 / 血管弛緩作用 / 短後毛様動脈 / 血管弛緩 / 非動脈炎性虚血性視神経症 / ラットモデル / ステロイド |
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| Outline of Final Research Achievements |
After induction of rodent model of nonarteritic ischemic optic neuropathy, we randomized three kinds of drugs which include saline, arginine, and steroid and injected each of them to the model. A steroid treatment group showed the most retinal ganglion cell (RGC) survival effect at the 56days after the treatment. A transcorneal electric stimulation (TES) did not show the significant RGC survival effect and TES plus arginine injection showed the significant RGC survival effect.
A methylprednisolone dilate the posterior ciliary artery in a dose dependent manner. In addition, they dilate these through nitric oxide independent mechanism.
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