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Examination of suppressive effect by combined treatment of atropine 0.01% ophthalmic solution and orthokeratology on myopia progression

Research Project

Project/Area Number 26462646
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionJichi Medical University

Principal Investigator

KINOSHITA Nozomi  自治医科大学, 医学部, 講師 (00382846)

Co-Investigator(Kenkyū-buntansha) 梯 彰弘  自治医科大学, 医学部, 教授 (30296123)
Research Collaborator KONNO Yasuhiro  こんの眼科, 院長
HAMADA Naoki  大宮はまだ眼科, 院長
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords0.01%アトロピン点眼薬 / オルソケラトロジー / 近視進行抑制 / 眼軸長伸展抑制 / 学童近視 / 近視進行予防 / 低濃度アトロピン点眼薬 / 0.01%アトロピン点眼薬
Outline of Final Research Achievements

Myopia progression in children is driven largely by axial length elongation. We investigated the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution in slowing axial elongation. Boys and girls aged 8 to 12 years with a spherical equivalent refractive error (SER) of -1.00 to -6.00 dioptres (D) were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group), or monotherapy with OK (monotherapy group). The combination group suppressed significantly axial elongation over 1 year but not over 2 years compared to the monotherapy group. However, in the subgroup of subjects with a SER of -1.00 to -3.00 D, axial elongation over 2 year was significantly suppressed by the combination group compared to the monotherapy group. The combination of OK and atropine 0.01% ophthalmic solution was more effective than monotherapy with OK in children with lower myopia, especially during the first year.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 Other

All Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (4 results)

  • [Presentation] Suppressive effect of combined treatment of orthokeratology and 0.01% atropine instillation on axial length elongation in childhood myopia2017

    • Author(s)
      Nozomi Kinoshita, Yasuhiro Konno, Naoki Hamada, Akihiro Kakehashi1
    • Organizer
      ARVO 2017
    • Place of Presentation
      Baltimore, USA
    • Year and Date
      2017-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 子供の近視におけるオルソケラトロジーと0.01%アトロピン点眼の併用による眼軸長伸展抑制の相加効果2017

    • Author(s)
      木下望
    • Organizer
      第2回近視研究会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Suppressive effect of combined treatment of orthokeratology and 0.01% atropine instillation on axial length elongation in childhood myopia2017

    • Author(s)
      Nozomi Kinoshita, Yasuhiro Konno, Naoki Hamada, Akihiro Kakehashi
    • Organizer
      ARVO 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オルソケラトロジーと0.01%アトロピン点眼の併用治療の検討(9ヶ月間の眼軸長変化)2016

    • Author(s)
      木下望、今野泰宏、濱田直紀、梯彰弘
    • Organizer
      第70回日本臨床眼科手術学会
    • Place of Presentation
      京都、日本
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Remarks] 木下望 - 研究者

    • URL

      https://researchmap.jp/nozomik1012/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 近視進行予防研究の参加者募集のご案内

    • URL

      http://www.jichi.ac.jp/center/sinryoka/g_eye/kinshi_yobou.pdf

    • Related Report
      2016 Research-status Report
  • [Remarks] 木下望 - 研究者 - researchmap

    • URL

      http://researchmap.jp/nozomik1012/

    • Related Report
      2016 Research-status Report 2015 Research-status Report 2014 Research-status Report
  • [Remarks] 近視進行予防研究の参加者募集のご案内

    • URL

      http://www.jichi.ac.jp/center/g_eye/kinshi_yobou.pdf

    • Related Report
      2015 Research-status Report 2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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