| Project/Area Number |
26462646
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
梯 彰弘 自治医科大学, 医学部, 教授 (30296123)
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| Research Collaborator |
KONNO Yasuhiro こんの眼科, 院長
HAMADA Naoki 大宮はまだ眼科, 院長
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 0.01%アトロピン点眼薬 / オルソケラトロジー / 近視進行抑制 / 眼軸長伸展抑制 / 学童近視 / 近視進行予防 / 低濃度アトロピン点眼薬 / 0.01％アトロピン点眼薬 |
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| Outline of Final Research Achievements |
Myopia progression in children is driven largely by axial length elongation. We investigated the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution in slowing axial elongation. Boys and girls aged 8 to 12 years with a spherical equivalent refractive error (SER) of -1.00 to -6.00 dioptres (D) were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group), or monotherapy with OK (monotherapy group). The combination group suppressed significantly axial elongation over 1 year but not over 2 years compared to the monotherapy group. However, in the subgroup of subjects with a SER of -1.00 to -3.00 D, axial elongation over 2 year was significantly suppressed by the combination group compared to the monotherapy group. The combination of OK and atropine 0.01% ophthalmic solution was more effective than monotherapy with OK in children with lower myopia, especially during the first year.
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