Analysis of interaction between local, systemic and genetic factors of keloid development.
| Project/Area Number |
26462737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Ogawa Rei 日本医科大学, 大学院医学研究科, 大学院教授 (70398866)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 創傷治癒 / ケロイド / 肥厚性瘢痕 / 瘢痕 / 血管内皮細胞 / 血管内皮前駆細胞 / 線維芽細胞 / メカノバイオロジー |
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| Outline of Final Research Achievements |
①The 204 cases were analyzed by GWAS. Assessment of rs8032158 revealed that in the dominant mode of inheritance, the severe keloid group had significant ORs compared with both the controls and the mild keloid group. Thus, rs8032158 associated strongly with severe keloids.
②The retrospective cross-sectional study involved 304 consecutive patients with keloids who were surgically treated in our hospital. Their blood pressure (BP), age and gender, and the size and number of their keloids before surgery were recorded. Ordinal logistic regression analyses showed that BP associated significantly with both keloid size and number.
③Vascular endothelial cells were sorted by magnetic activated cell sorter. Gene expression of these cells is studied. The analysis is undergoing.
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Report
(4 results)
Research Products
(4 results)
