Immunoparalysis and analysis of hematopoietic stem cell in sepsis:a trial of regenerative immunoactivity by bone-marrow transplantation
| Project/Area Number |
26462771
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nagoya City University (2015-2017)
Fujita Health University (2014) |
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Principal Investigator |
Hattori Tomonori 名古屋市立大学, 大学院医学研究科, 教授 (90363936)
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| Co-Investigator(Kenkyū-buntansha) |
武山 直志 愛知医科大学, 医学部, 准教授 (00155053)
秦 龍二 藤田保健衛生大学, 医学部, 教授 (90258153)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / 免疫不全 / 骨髄移植 / T細胞 / 骨髄幹細胞 / immunoparalysis / 骨髄幹細胞移植 |
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| Outline of Final Research Achievements |
In septic shock patients, serial blood samples were obtained on days 1, 3, and 7 after the onset of shock, and immune cell subsets and receptor expression were characterized. A decrease of immunoactivity of T cells and monocyte were observed in the early stage of septic shock. Significant lymphopenia persisted for at least 7 days following the onset of septic shock. Normalization of immunodysfunctions was observed by day 7, except in patients who died. Our findings emphasize the importance of normal lymphocyte function for recovery from septic shock. These results indicate that the regeneration of the immunoparalytic state by bone-marrow transplantation, can be potentially effective therapy for recovery from septic shock.
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Report
(5 results)
Research Products
(28 results)
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[Journal Article] Complementary Role of Hypothermia Identification to the Quick Sequential Organ Failure Assessment Score in Predicting Patients With Sepsis at High Risk of Mortality: A Retrospective Analysis From a Multicenter, Observational Study.2018
Author(s)
Kushimoto S, Gando S, Ogura H, Umemura Y, Saitoh D, Mayumi T, Fujishima S, Abe T, Shiraishi A, Ikeda H, Kotani J, Miki Y, Shiraishi SI, Suzuki K, Suzuki Y, Takeyama N, Takuma K, Tsuruta R, Yamaguchi Y, Yamashita N, Aikawa N.
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Journal Title
J Intensive Care Med
Volume: -
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Early evaluation of severity in patients with severe sepsis: a comparison with "septic shock" - subgroup analysis of the Japanese Association for Acute Medicine Sepsis Registry (JAAM-SR).2017
Author(s)
Tarui T, Yamaguchi Y, Suzuki K, Tsuruta R, Ikeda H, Ogura H, Kushimoto S, Kotani J, Shiraishi SI, Suzuki Y, Takuma K, Takeyama N, Fujishima S, Mayumi T, Miki Y, Yamashita N, Aikawa N, Gando S.
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Journal Title
Acute Med Surg
Volume: 4(4)
Pages: 426-431
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Assessment of mortality by qSOFA in patients with sepsis outside ICU: A post hoc subgroup analysis by the Japanese Association for Acute Medicine Sepsis Registry Study Group.2017
Author(s)
Umemura Y, Ogura H, Gando S, Kushimoto S, Saitoh D, Mayumi T, Fujishima S, Abe T, Ikeda H, Kotani J, Miki Y, Shiraishi SI, Shiraishi A, Suzuki K, Suzuki Y, Takeyama N, Takuma K, Tsuruta R, Yamaguchi Y, Yamashita N, Aikawa N
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Journal Title
J Infect Chemother
Volume: 23(11)
Pages: 757-762
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] A290- Ex vivo and in vivo generation of neutropil extracellular traps by neutrophils from septic patients.2015
Author(s)
Takeyama N, Huq MA, Ando M, Gocho T, Hashiba M, Miyabe H, Kano H, Tomino A, Tsuda M, Hattori T, Hirakawa A
Organizer
35th International Symposium on Intensive Care and Emergebcy Medicine
Place of Presentation
Brussels, Belgium
Year and Date
2015-03-17 – 2015-03-20
Related Report
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[Presentation] 当院の血液浄化の現状2015
Author(s)
服部友紀、武山直志、他
Organizer
第42回日本集中治療医学会総会・学術集会,
Place of Presentation
東京都ホテル日航東京
Year and Date
2015-02-09 – 2015-02-11
Related Report
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