Analysis of expression mechanisms and adhesive functions of streptococal pili
Project/Area Number |
26462779
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphological basic dentistry
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
川端 重忠 大阪大学, 歯学研究科, 教授 (50273694)
住友 倫子 大阪大学, 歯学研究科, 助教 (50423421)
岡橋 暢夫 大阪大学, 歯学研究科, 准教授 (40150180)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 化膿レンサ球菌 / 線毛 / レンサ球菌 |
Outline of Final Research Achievements |
The human pathogen group A Streptococcus pyogenes causes a wide variety of diseases, ranging from superficial purulent infections of the pharynx and skin to invasive infections. During the pathological process, Streptococcus pyogenes senses diverse environmental and host factors, and exhibits modulation of secretory proteins. We examined whether environmental temperature has effects on pilus expression of S. pyogenes. Experiments using clinically relevant serotypes revealed that strains possessing distinct genotypes of a chromosomal region showed temperature-dependent pilus expression, which was attributed to translation efficiency of a transcriptional regulator. Thus, the findings indicate that Streptococcus pyogenes responds to environmental temperature and modulates expression of adhesins.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide.2017
Author(s)
Sumioka, R., Nakata, M., Okahashi, N., Li, Y., Wada, S., Yamaguchi, M., Sumitomo, T., Hayashi, M., Kawabata, S.
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Journal Title
PLoS One
Volume: 12
Issue: 2
Pages: e0172223-e0172223
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Degradation of bradykinin by a metalloendopeptidase from Streptococcus pyogenes.2016
Author(s)
Miyamoto, T., Akaike, T., Kawabata, S., Akuta, T., Taruki, C., Yoshitake, J., Hamada, S., Ota, F., Ikarashi, H., Yoshimura, K., Kamijo, R., Maeda, H.
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Journal Title
Journal of Oral Biosciences
Volume: 58
Issue: 4
Pages: 167-172
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum.2016
Author(s)
Oogai, Y., Yamaguchi, M., Kawada-Matsuo, M., Sumitomo, T., Kawabata, S., Komatsuzawa, H.
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Journal Title
Applied and Environmental Microbiology
Volume: 82
Issue: 20
Pages: 6150-6157
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Evolutionary inactivation of a sialidase ingroup B Streptococcus.2016
Author(s)
Yamaguchi, M., Hirose, Y., Nakata, M., Uchiyama, S., Yamaguchi, Y., Goto, K., Sumitomo, T., Lewis, A., Kawabata, S., Nizet, V.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 28852-28852
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effects of extracellular pH on Dental Pulp Cells in Vitro2016
Author(s)
Hirose, Y., Yamaguchi, M., Kawabata, S., Murakami, M., Nakashima, M., Gotoh, M., Yamamoto, T.
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Journal Title
Journal of endodontics
Volume: 印刷中
Issue: 5
Pages: 735-741
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Enzymatically active extracellular hyaluronidase (HylA) of group A Streptococcus promotes intracellular survival and virulence.2014
Author(s)
Yamaguchi M, Yamaguchi Y, Nakata M, Henningham A, Olson J, Dahesh S, Cole J, Kawabata S, Varki A, and Nizet V.
Organizer
SFG and JSCR2014 Joint Annual Meeting.
Place of Presentation
Honolulu, HI, USA.
Year and Date
2014-11-16 – 2014-11-19
Related Report
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