Coding of bitter taste information among taste bud cells
| Project/Area Number |
26462815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 味覚 / 苦味 / 味細胞 / 受容体 / 情報伝達機構 / 遺伝子改変マウス / 細胞内情報伝達 / コレシストキニン / 味覚受容機構 / 電気生理 |
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| Outline of Final Research Achievements |
This study has demonstrated that (1) Bitter sensitive taste cells are heterogeneous from the point of view of their responsiveness, (2) Overall response profile of bitter taste cells to multiple bitter compounds was not significantly different between fungiform and circumvallate papillae, (3) Bitter responses of taste cells were significantly suppressed by TRPM5 inhibitor and PLC inhibitor, (4) Bitter responses of mouse taste cells were not affected by human bitter receptor antagonists, (5) CCK may be involved in peripheral bitter taste signaling. These data help understanding receptors and transduction mechanisms for bitter taste and give insights into coding of bitter taste information in the peripheral taste system.
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Report
(4 results)
Research Products
(26 results)
