Thirst induce by acetaldehyde

• Project/Area Number: 26462819
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional basic dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: INENAGA Kiyotoshi 九州歯科大学, 歯学部, 名誉教授 (90131903)
• Co-Investigator(Kenkyū-buntansha): 小野 堅太郎 九州歯科大学, 歯学部, 教授 (40316154) ; 人見 涼露 九州歯科大学, 歯学部, 助教 (70548924)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: アセトアルデヒド / 喉の渇き / アンギオテンシン / 二日酔い / 口渇中枢 / アンジオテンシンⅡ / レニン / マスト細胞 / エタノール / ヒスタミン / 脳弓下器官

Outline of Final Research Achievements

The sensation of thirst experienced after heavy alcohol drinking is widely regarded as a consequence of ethanol (EtOH)-induced diuresis, but EtOH in high doses actually induces anti-diuresis. The present study was designed to investigate the introduction mechanism of water and salt intake after heavy alcohol drinking, focusing on action of acetaldehyde, a metabolite of EtOH and a toxic substance, using rats. Systemic administration of a high-dose of EtOH at 2.5 g/kg induced water and salt intake with anti-diuresis. Our results suggest that acetaldehyde evokes the thirst sensation following heavy alcohol drinking, by two distinct and previously unsuspected mechanisms, independent of diuresis. First acetaldehyde indirectly activates AT1R in the dipsogenic centers via the peripheral renin-angiotensin system following the depressor response and induces both water and salt intake. Secondly acetaldehyde directly activates neurons in the dipsogenic centers and induces only water intake.

Research Products

• [Journal Article] Thirst sensation and oral dryness followng aclohol intake (2017)
  • Author(s): Inenaga K, Ono K, Hitomi S, Kuroki A, Ujihara I
  • Journal Title: Japanese Dental Science Review Volume: 53
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The ethanol metabolite acetaldehyde induces water and salt intake via two distinct pathways in the central nervous system of rats (2015)
  • Author(s): Ujihara I, Hitomi S, Ono K, Kakinoki Y, Hashimoto H, Ueta Y, Inenaga K
  • Journal Title: Neuropharmacology Volume: 99 Pages: 589-599
  • DOI: 10.1016/j.neuropharm.2015.08.023
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] アンジオテンシンⅡと喉の渇き (2015)
  • Author(s): 稲永清敏
  • Organizer: 三叉神経領域の感覚－運動統合機能研究会,
  • Place of Presentation: 福岡
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] The ethanol metabolite acetaldehyde induces the sensation of thirst (2015)
  • Author(s): 氏原泉、人見涼露、小野堅太郎、柿木保明、稲永清敏
  • Organizer: 第92回日本生理学会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Acetaldehyde induces thirst sensation through the renin-angiotensin system in rats. (2014)
  • Author(s): I. Ujihara, S. Hitomi, K. Ono, Y. Kakinoki, K. Inenaga.
  • Organizer: Neuroscience Meeting
  • Place of Presentation: ワシントン
  • Year and Date: 2014-11-15 – 2014-11-21
• [Presentation] 二日酔い時の喉の渇きはアセトアルデヒドが原因で起こる (2014)
  • Author(s): 氏原泉、人見涼露、小野堅太郎、柿木保明、稲永清敏
  • Organizer: 西日本生理学会
  • Place of Presentation: 沖縄
  • Year and Date: 2014-10-23 – 2014-10-24
• [Presentation] 二日酔いでの口渇感はアセトアルデヒド誘発レニン・アンジオテンシン系の活性化により起こる (2014)
  • Author(s): 氏原泉、人見涼露、小野堅太郎、柿木保明、稲永清敏
  • Organizer: 第56回歯科基礎医学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 飲酒後の喉の渇きはレニン・アンジオテンシン系が関与する (2014)
  • Author(s): 氏原泉、人見涼露、小野堅太郎、柿木保明、稲永清敏
  • Organizer: 第74回九州歯科学会
  • Place of Presentation: 北九州
  • Year and Date: 2014-05-31 – 2014-06-01