| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Although the pathogenesis of oral lichen planus (OLP) has not been elucidated, the possibility of an immune response based on localized excessive cytokine toward mucosal epithelial cells has been suggested. In this study, we investigated whether the activation of NLRP3 inflammasome is involved in the pathogenesis of OLP. As a result, it was revealed that the activation of NLRP3 inflammasome by metal nanoparticles in the oral mucosal epithelial cells and macrophages was involved with the pathogenesis of OLP.
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