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A basic study of fluorapatite-forming calcium phosphate cement with calcium silicate

Research Project

Project/Area Number 26462898
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionNihon University

Principal Investigator

HAYASHI Makoto  日本大学, 歯学部, 准教授 (00301557)

Research Collaborator CHOW Laurence C.  
TAKAGI Shozo  
SUZUKI Yusuke  
YASUKAWA Takuya  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯内療法用セメント / リン酸カルシウムセメント / フルオロアパタイト / ケイ酸カルシウム / リン酸カルシウム / 歯内治療用セメント
Outline of Final Research Achievements

Mineral trioxide aggregate (MTA) is a promising biomaterial in endodontic treatments. However, a disadvantage of this material is its difficult handling properties, namely, relatively long setting times. Thus, a need has been identified for the development of materials more suitable for endodontic applications. Calcium phosphate cement (CPC) has become a subject of interest in medical applications as bone graft biomaterials. For endodontic treatments, fluorapatite-forming CPC with tricalcium silicate (FA-forming CPC with TCS) was developed and evaluated for endodontic cements.
In results, setting time of FA-forming CPC with TCS was shorter than that of MTA, on the other hand, it has similar sealing ability and biocompatibility as those of MTA. These results suggested that FA-forming CPC with TCS had an appropriate characteristic as endodontic cements. Therefore, FA-forming CPC with TCS may be useful for endodontic applications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] American Dental Association Foundation/Anthony Volpe Research Center/NIST(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] American Dental Association Foundation/Dr. Anthony Volpe Research Center/NIST(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Involvement of the calcium-sensing receptor in mineral trioxide aggregate-induced osteogenic gene expression in murine MC3T3-E1 cells2017

    • Author(s)
      T. Yasukawa, M. Hayashi, N. Tanabe, H. Tsuda, Y. Suzuki, T. Kawato, N. Suzuki and B. Ogiso
    • Journal Title

      Dental Materials Journal

      Volume: 36 Issue: 4 Pages: 469-475

    • DOI

      10.4012/dmj.2016-313

    • NAID

      130005865142

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] <i>In Vitro</i> Properties of Fluorapatite-forming Calcium Phosphate Cements2016

    • Author(s)
      H. Ogata, S. Takagi, M. Hayashi, T. Yasukawa, H. Ibi, Y. Hirano, Y. Suzuki, S. Matsuura, B. Ogiso and LC. Chow
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 59 Issue: 6 Pages: 472-478

    • DOI

      10.11471/shikahozon.59.472

    • NAID

      130005239823

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] MTAの生物学的特性 ―細胞,組織に対する作用―2016

    • Author(s)
      林  誠,小木曾文内
    • Journal Title

      日本歯科理工学会誌

      Volume: 35 Pages: 241-244

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of a laser displacement sensor with a non-contact electromagnetic vibration device for assessment of simulated periodontal tissue conditions2016

    • Author(s)
      H. Kobayashi, M. Yamaoka, M. Hayashi, B. Ogiso
    • Journal Title

      Journal of Oral Science

      Volume: 58 Issue: 1 Pages: 93-99

    • DOI

      10.2334/josnusd.58.93

    • NAID

      130005139527

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 偶発症由来の難治性根尖性歯周炎の診断と治療 ―治りにくい根管治療の患者さんが来院したら―2015

    • Author(s)
      武市 収,林 誠,小木曾文内
    • Journal Title

      東京都歯科医師会雑誌

      Volume: 63 Pages: 513-520

    • Related Report
      2015 Research-status Report
  • [Journal Article] レジン系根管シーラー(リアルシールSEシーラー)の歯根象牙質に対する接着性に関する研究 ―象牙質表面処理およびシーラー硬化時荷重の影響―2015

    • Author(s)
      小森規雄,林 誠,小林 寛,牧野公亮,安川拓也,井比陽奈,小木曽文内
    • Journal Title

      日大歯学

      Volume: 89 Pages: 113-117

    • NAID

      40020583522

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a novel fluorapatite-forming calcium phosphate cement with calcium silicate: <i>In vitro</i> and <i>in vivo</i> characteristics2015

    • Author(s)
      Y. Suzuki, M. Hayashi, T. Yasukawa, H. Kobayashi, K. Makino, Y. Hirano, S. Takagi, LC. Chow and B. Ogiso
    • Journal Title

      Dental Materials Journal

      Volume: 34 Issue: 2 Pages: 263-269

    • DOI

      10.4012/dmj.2014-255

    • NAID

      130005062402

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 新規歯内治療用セメントの開発に関する基礎的研究2015

    • Author(s)
      林  誠
    • Journal Title

      日本大学歯学部同窓会会誌

      Volume: 59 Pages: 9-11

    • Related Report
      2014 Research-status Report
  • [Presentation] 骨芽細胞におけるcalcium-sensing receptorを介したmineral trioxide aggregateによる骨形成誘導2017

    • Author(s)
      安川拓也,林  誠,黄 紀蓉,田邉奈津子,川戸貴行,小木曽文内
    • Organizer
      第146回春季日本歯科保存学会
    • Place of Presentation
      リンクステーションホール青森(青森市・青森))
    • Year and Date
      2017-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mineral trioxide aggregateによる骨芽細胞の分化促進に及ぼすCalcium-sensing receptorの関与2016

    • Author(s)
      安川拓也,林  誠,羽鳥啓介,田邉奈津子,川戸貴行,小木曽文内
    • Organizer
      第145回秋季日本歯科保存学会
    • Place of Presentation
      キッセイ文化ホール(松本市・長野)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mineral trioxide aggregateはcalcium-sensing receptorを介して骨芽細胞の分化を促進する2016

    • Author(s)
      安川拓也,林  誠,田邉奈津子,津田啓方,鈴木直人,前野正夫,小木曽文内
    • Organizer
      第25回硬組織再生生物学会
    • Place of Presentation
      日本大学歯学部(千代田区・東京)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bacterial leakage of fluorapatite-forming calcium phosphate cement containing tricalcium silicate2016

    • Author(s)
      M. Hayashi, M. Tamura, S. Takagi, L. Chow, K. Ochiai, B. Ogiso
    • Organizer
      45th Annual Meeting & Exhibition of the American Association for Dental Research
    • Place of Presentation
      Los Angeles Convention Center (Los Angeles, CA, USA)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Osteogenic gene expression induced by MTA via calcium-sensing receptor2016

    • Author(s)
      T. Yasukawa, M. Hayashi, N. Tanabe, H. Tsuda, N. Suzuki, B. Ogiso
    • Organizer
      45th Annual Meeting & Exhibition of the American Association for Dental Research
    • Place of Presentation
      Los Angeles Convention Center (Los Angeles, CA, USA)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Disinfection for endodontic treatment by ultrasound/LED activation of H2O22016

    • Author(s)
      H. Ibi, M. Hayashi, F. Yoshino, A. Yoshida, Y. Kobayashi, M. Tamura, K. Ochiai, B. Ogiso, M. Lee
    • Organizer
      45th Annual Meeting & Exhibition of the American Association for Dental Research
    • Place of Presentation
      Los Angeles Convention Center (Los Angeles, CA, USA)
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性歯髄炎により誘導される歯痛錯誤の末梢神経機構2015

    • Author(s)
      古宮宏記,清水康平,林  誠,鶴町 保,小木曾文内
    • Organizer
      第143回秋季日本歯科保存学会
    • Place of Presentation
      文京シビックホール(文京区・東京)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 試作非接触型電磁式加振装置に関する基礎的研究 -模擬歯根膜の性状変化がレーザー変位計によって測定した力学的パラメーターに及ぼす影響-2015

    • Author(s)
      小林 寛,林  誠,山岡 大,石井佳笑,古宮宏記,清水康平,鶴町 保,小木曾文内
    • Organizer
      第142回春季日本歯科保存学会
    • Place of Presentation
      北九州国際会議場(北九州市・福岡県)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 新たな根管清掃・消毒法に関する基礎的研究 -超音波とLEDの照射が過酸化水素水の活性酸素種生成に及ぼす影響-2015

    • Author(s)
      井比陽菜,林  誠,吉野文彦,田村宗明,吉田彩佳,李 昌一,平野頼是,小林慶美,落合邦康,小木曽文内
    • Organizer
      第142回春季日本歯科保存学会
    • Place of Presentation
      北九州国際会議場(北九州市・福岡県)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Presentation] Using a laser displacement sensor for non-contact electromagnetic vibration measurements2015

    • Author(s)
      H. Kobayashi, M. Hayashi, Y. Hirano, Y. Suzuki, H. Ibi, T.Yasukawa, M. Yamaoka, B. Ogiso
    • Organizer
      93RD General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      Hynes Convention Center (Boston, MA, USA)
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯周組織の客観的評価法に関する基礎的研究 -試作非接触型電磁式加振装置に対するレーザー変位計の応用-2014

    • Author(s)
      小林 寛,林  誠,武市 収,羽鳥啓介,牧野公亮,小木曽文内
    • Organizer
      第35回日本歯内療法学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2014-07-12 – 2014-07-13
    • Related Report
      2014 Research-status Report
  • [Presentation] NEX MTAセメントが骨芽細胞の石灰化に及ぼす影響2014

    • Author(s)
      鈴木裕介,林  誠,安川拓也,鈴木奈お,鶴町 保,鈴木直人,小木曽文内
    • Organizer
      第140回春季日本歯科保存学会
    • Place of Presentation
      滋賀県立芸術劇場(滋賀県・大津市)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-16  

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