Effects of alkali-heated titanium surface on function of gingival fibroblasts and achievement of connective tissue attachment
Project/Area Number |
26462978
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
|
Research Institution | Tohoku University (2015-2016) Tokyo Dental College (2014) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
櫻井 薫 東京歯科大学, 歯学部, 教授 (20153950)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 線維芽細胞 / 歯肉 / ナノテクノロジー / チタン / 表面改質 / 結合組織 / 生体模倣 / ナノ形状 / インプラント周囲組織 / 結合組織性付着 / 歯肉線維 |
Outline of Final Research Achievements |
One disadvantage of titanium implants effective for reconstruction of dental / maxillofacial defects is that they do not adhere to the connective tissue layer of the gingival tissue and skin. The purpose of this study is to develop titanium implants adhering to connective tissue by forming nano-topography on titanium surface using alkali-heat treatment. Titanium surface subjected to alkali-heat treatment under specified conditions exhibited nano-topography characterized by numerous nano-pores and dense nano-spikes. The nano-titanium surface increased the amount of collagen production from rat gingival and human dermal fibroblasts and the adhesion strength of extracellular matrix. In the rabbit maxilla model, it was demonstrated that the nano-titanium surface implant encapsulated the end of gingival fiber within the surface and acquired periodontal-like like connective tissue attachment.
|
Report
(4 results)
Research Products
(77 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] 認知症患者の歯科治療に対する疑問と問題点―Clinical Question調査から―2016
Author(s)
服部佳功,枝広あや子,渡邊 裕,平野浩彦,古屋純一,中島純子,田村文誉,北川 昇,堀 一浩,原 哲也,吉川峰加,西 恭宏,永尾 寛,市川哲雄,櫻井 薫
-
Journal Title
老年歯科医学
Volume: 31
Pages: 3-8
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] 高齢期における口腔機能低下 ―学会見解論文 2016年度版―2016
Author(s)
水口俊介,津賀一弘,池邉一典,上田貴之,田村文誉,永尾 寛,古屋純一,松尾浩一郎,山本 健,金澤 学,渡邊 裕,平野浩彦,菊谷 武,櫻井 薫
-
Journal Title
老年歯科医学
Volume: 31
Pages: 81-99
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] 急性期病院入院高齢者における口腔機能低下と低栄養との関連性2016
Author(s)
松尾浩一郎,金澤 学, 古屋純一, 津賀一弘, 池邉一典, 上田貴之, 田村文誉, 永尾 寛, 山本 健, 櫻井 薫, 水口俊介
-
Journal Title
老年歯科医学
Volume: 31
Pages: 123-133
NAID
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] UV photofunctionalization promotes nano-biomimetic apatite deposition on titanium.2016
Author(s)
Saita, M., Ikeda, T., Yamada, M., Kimoto, K., Lee, MC., Ogawa, T.
-
Journal Title
Int J Nanomedicine.
Volume: 12
Pages: 223-234
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
[Presentation] Accuracy of optical impression for edentulous region2017
Author(s)
Tasaka A, Uekubo Y, Mitsui T, Kasahara T, Takanashi T, Homma S, Matsunaga S, Abe S, Yoshinari M, Yajima Y, Sakurai K, Yamashita S.
Organizer
2017 IADR/APR General Session & Exhibition
Place of Presentation
San Francisco, USA
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
[Presentation] 地域在住高齢者における咬合力および咀嚼能力の低下とフレイルとの関連2016
Author(s)
堀部耕広,平野浩彦,渡邊 裕,枝広あや子,小原由紀,本川佳子,白部麻樹,吉田英世,大渕修一,上田貴之,櫻井 薫
Organizer
第301回東京歯科大学学会(例会)
Place of Presentation
東京
Related Report
-
-
[Presentation] 悪性腫瘍周術期での舌圧,咬合力,握力の変化 ―日本老年歯科医学会学術委員会主導研究(プロジェクト藤田)―2016
Author(s)
町田奈美,櫻井 薫, 松尾浩一郎,谷口裕重,中川量晴,金澤 学,古屋純一,津賀一弘,池邊一典,上田貴之,田村文誉,永尾 寛,山本 健,水口俊介
Organizer
日本老年歯科医学会第27回学術大会
Place of Presentation
徳島
Related Report
-
[Presentation] 入院高齢者における口腔衛生状態と栄養状態 ―日本老年歯科医学会学術委員会主導研究(プロジェクト藤田)―2016
Author(s)
中川量晴,松尾浩一郎,町田奈美,金澤 学,古屋純一,谷口裕重,津賀一弘, 池邊一典,上田貴之,田村文誉,永尾 寛,山本 健,櫻井 薫,水口俊介
Organizer
日本老年歯科医学会第27回学術大会
Place of Presentation
徳島
Related Report
-
[Presentation] 入院患者における舌圧と栄養,握力との関連 ―日本老年歯科医学会学術委員会主導研究(プロジェクト藤田)―2016
Author(s)
谷口裕重, 松尾浩一郎, 町田奈美, 金澤 学,中川量晴,古屋純一,津賀一弘, 池邊一典,上田貴之,田村文誉,永尾 寛,山本 健,櫻井 薫,水口俊介
Organizer
日本老年歯科医学会第27回学術大会
Place of Presentation
徳島
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-