Regulation of chemoresistance by tumor-associated macrophages in oral squamous cell carcinoma cells

Research Project

Project/Area Number	26463012
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Surgical dentistry
Research Institution	Kochi University
Principal Investigator	SASABE Eri 高知大学, 教育研究部医療学系臨床医学部門, 講師 (40363288)
Co-Investigator(Kenkyū-buntansha)	山本哲也高知大学, 教育研究部医療学系臨床医学部門, 教授 (00200824) 北村直也高知大学, 教育研究部医療学系臨床医学部門, 講師 (70351921) 村田智子高知大学, 教育研究部医療学系, 助教 (00610916)
Research Collaborator	TOMITA Riki 高知大学, 医学部, 大学院生 (90759416)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	腫瘍関連マクロファージ / 口腔扁平上皮癌 / 抗がん剤 / 抗癌剤
Outline of Final Research Achievements	We investigated whether tumor-associated macrophages (TAM) are involved in the mechanism of acquired chemoresistance in oral squamous-cell carcinoma (OSCC). As a result, it was revealed that exosomes secreted by TAM promotes the proliferative capacity of OSCC cells and reduces the anti-cancer drug sensitivity through regulation of the cell cycle and suppression of apoptosis. Therefore, it was suggested that TAM may decrease sensitivity to anti-cancer drugs through secretion of exosomes in the tumor microenvironment.