The analysis of the invasion mechanism of oral squamous cell carcinoma induced by new EMT-related gene MTDH

• Project/Area Number: 26463043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Ono Shigehiro 広島大学, 医歯薬保健学研究院(歯), 助教 (70379882)
• Co-Investigator(Kenkyū-buntansha): 武知 正晃 広島大学, 医歯薬保健学研究院(歯), 准教授 (00304535) ; 飛梅 圭 広島大学, 医歯薬保健学研究院(歯), 准教授 (40350037) ; 重石 英生 広島大学, 医歯薬保健学研究院(歯), 助教 (90397943)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口腔癌 / 高度浸能 / 浸潤 / 転移 / 上皮間葉移行 / 癌幹細胞

Outline of Final Research Achievements

We studied for the purpose of clarifying the details of the mechanism of EMT which gave to the acquisition of high invasive ability of oral squamous cell carcinoma that Metadherin (MTDH) which we found induced.We investigated in detail a cell motility, an overexpression of the substrate degrading enzyme and a decreased expression of cell adhesion factor we have researched and examined ever.These results suggest that MTDH may relate with the acquisition of high infiltration ability of the oral squamous cell carcinoma cell.In addition, it was suggested that the acquisition of infilitration ability can relate to the acquisition of the stem cell-like form closely.

Research Products

• [Journal Article] Preoperative oral health care reduces postoperative inflammation and complications in oral cancer patients. (2016)
  • Author(s): Shigeishi H, Ono S, Higashikawa K, Tada M, Ishida F, Okui G, Okumura T, Fukui A, Kubozono K, Yamamoto K, Ishida Y, Seino S, Hashikata M, Sasaki K, Naruse T, Rahman MZ, Uetsuki R, Nimiya A, Takamoto M, Dainobu K, Tokikazu T, Nishi H, Sugiyama M, Takechi M.
  • Journal Title: Exp Ther Med. Volume: 12 Issue: 3 Pages: 1922-1928
  • DOI: 10.3892/etm.2016.3532
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3β-dependent cancer stem cell properties. (2016)
  • Author(s): Seino S, Shigeishi H, Hashikata M, Higashikawa K, Tobiume K, Uetsuki R, Ishida Y, Sasaki K, Naruse T, Rahman MZ, Ono S, Simasue H, Ohta K, Sugiyama M, Takechi M.
  • Journal Title: J Oral Pathol Med Volume: 45 Issue: 3 Pages: 180-188
  • DOI: 10.1111/jop.12348
  • Peer Reviewed / Open Access
• [Presentation] 口腔扁平上皮癌細胞における幹性とEMTとの関連性についてのin vitro解析 (2016)
  • Author(s): 植月亮，東川晃一郎，重石英生，石田扶美，小野重弘，島末洋，武知正晃
  • Organizer: 第61回日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張