Establishment of the new oral cancer treatment strategy by elucidation of the lymph node metastasis mechanism

• Project/Area Number: 26463047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: Goda Hiroyuki 愛媛大学, 医学部附属病院, 講師 (00464371)
• Co-Investigator(Renkei-kenkyūsha): Masato Okamoto 北里大学, 薬学部, 教授 (10243718)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 口腔癌 / 癌免疫 / リンパ節転移 / バイオマーカー / IL-6 / interleukin-6 / CAF / VEGF-A / VEGF-C

Outline of Final Research Achievements

We found that the sentinel lymph node expression of VEGF-C, Foxp3, CD68 and CD163 are higher than non-sentinel lymph node. And the expression of PDL1 in primary tumor with metastatic lymph node patients was higher than non lymph node metastasis patients. And we examined sera derived from OSCC patients for multiple cytokines by using a multiplexed measurement system, and the results showed that the serum IL-6 and IL-8 level tended to negatively correlate with favorable outcome in these patients disease-free survival (DFS) was significantly longer in the Stage I/II OSCC patients with low serum IL-6/8 levels compared to those with high levels.

Research Products

• [Journal Article] Prognostic impact of preoperative serum interleukin-6 levels in early stage oral squamous cell carcinoma patients strictly defined by sentinel node biopsy. (2016)
  • Author(s): Goda H, Okamoto M, Nakashiro K, Hino S, Murase R, Hamakawa H.
  • Journal Title: oncology letters Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Annexin A8 is a novel molecular marker for detecting lymph node metastasis in oral squamous cell carcinoma. (2016)
  • Author(s): Oka R, Nakashiro K, Goda H, Iwamoto K, Tokuzen N, Hamakawa H.
  • Journal Title: oncotarget Volume: 7(4) Issue: 4 Pages: 4882-9
  • DOI: 10.18632/oncotarget.6639
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 口腔癌におけるセンチネルリンパ節生検の現状と課題 (2016)
  • Author(s): 合田啓之、中城公一、日野聡史、村瀬隆一、浜川知大、浜川裕之
  • Organizer: 第 34 回日本口腔腫瘍学会総会学術大会
  • Place of Presentation: 横浜市開港記念会館、横浜市、神奈川県
  • Year and Date: 2016-01-21
  • Invited
• [Presentation] 口腔扁平上皮癌における Interleukin-6 シグナルを標的とした治療アプローチの検討 (2016)
  • Author(s): 合田啓之
  • Organizer: 第 70 回日本口腔科学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
• [Presentation] 口腔扁平上皮癌における予後予測因子としてのバイオマーカーの探索 (2016)
  • Author(s): 合田啓之
  • Organizer: 第 54 回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] Anti-interleukin-6 receptor antibody suppressed oral squamous cell carcinoma by inhibiting tumor-stroma interaction. (2015)
  • Author(s): Goda H, Okamoto M, Nakashiro K, Tokuzen N, Hamakawa H.
  • Organizer: ESMO in Asia
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre, Suntec City, Singapore
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] 口腔扁平上皮癌における腫瘍関連線維芽細胞の臨床的意義 (2015)
  • Author(s): 合田啓之、岡本正人、徳善紀彦、中城公一、浜川裕之
  • Organizer: 第 53 回日本癌治療学会学術集会
  • Place of Presentation: 京都国際会議場、京都市、京都府
  • Year and Date: 2015-10-29
• [Presentation] 口腔癌における SNNS の現状と今後の展望 (2014)
  • Author(s): 合田啓之
  • Organizer: 第 16 回 SNNS 研究会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2014-09-19 – 2014-09-20
  • Invited
• [Presentation] Clinical implication of interleukin-6 and angiogenesis in cN0 oral cancer strictly defined by sentinel node biopsy (2014)
  • Author(s): Hiroyuki Goda
  • Organizer: 96th American Association of Oral and Maxillofacial Surgery Annual Meeting
  • Place of Presentation: Hawaii
  • Year and Date: 2014-09-08 – 2014-09-13