| Project/Area Number |
26463070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北畑 洋 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (60161486)
川人 伸次 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (60284296)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 血管新生 / 静脈麻酔 / 静脈麻酔薬 / 血管内皮細胞増殖因子 / 細胞増殖 / 細胞遊走 / 血管内皮 |
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| Outline of Final Research Achievements |
The detailed effects of anesthetics on angiogenesis have not yet been clarified. Angiogenesis is composed of some processes: the release of regulators as such vascular endothelial growth factor (VEGF), cell proliferation, migration, and tube formation. The aim of this study was to determine the effects of intravenous anesthetics on the release of VEGF, cell proliferation, cell migration and in vitro capillary tube formation. As the results, midazolam and diazepam but not propofol and ketamine significantly increased the release of VEGF in A10 cells in a dose dependent manner. Fifty μM of midazolam significantly impaired endothelial cell migration and in vitro capillary tube formation. Diazepam, propofol and ketamine did not show any enhancing or suppressive effects on cell proliferation, cell migration and capillary tube formation. Dexmedetomidine did not show any effects on cell proliferation and cell migration.
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