Potential role of IL-1 family cytokines in periodontal diseases

• Project/Area Number: 26463150
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Osaka Medical College (2016); Hyogo Medical University (2014-2015)
• Principal Investigator: Ohyama Hideki 大阪医科大学, 医学部, 非常勤講師 (90280685)
• Co-Investigator(Kenkyū-buntansha): 中正 恵二 兵庫医科大学, 医学部, 教授 (00217712) ; 山根木 康嗣 兵庫医科大学, 医学部, 講師 (00434944) ; 山田 直子 兵庫医科大学, 医学部, 講師 (10319858) ; 久保 秀司 兵庫医科大学, 医学部, 准教授 (10441320) ; 小越 菜保子 大阪医科大学, 医学部, 助教 (60509115)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IL-36 / 歯肉上皮細胞 / 歯周病 / ＩＬ－３６

Outline of Final Research Achievements

We evaluated the expression of IL-1 family cytokines in the periodontal tissue of periodontitis patients. We focused on the expression of IL-36γ as it was found to be highly expressed in the gingival epithelium. We found that the expression of IL-36γ in gingival epithelial cells was significantly induced by IL-1β, TNF-α, IL-17, and Porphyromonas gingivalis. In addition, the IL-36γ expression level increased with differentiation of gingival epithelial cells. These results suggest the potential role of IL36γ in periodontal diseases.

Research Products

• [Journal Article] Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene. (2016)
  • Author(s): Kato-Kogoe N, Ohyama H, Okano S, Yamanegi K, Yamada N, Hata M, Nishiura H, Abiko Y, Terada N, Nakasho K
  • Journal Title: Immunogenetics Volume: 68(1) Issue: 1 Pages: 55-65
  • DOI: 10.1007/s00251-015-0882-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expression of interleukin-34 and colony stimulating factor-1 in the stimulated periodontal ligament cells with tumor necrosis factor-α., (2015)
  • Author(s): Kawabe M, Ohyama H, Kato-Kogoe N, Yamada N, Yamanegi K, Nishiura H, Hirano H, Kishimoto H, Nakasho K.
  • Journal Title: Med Mol Morphol. Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expression of interleukin-34 and colony stimulating factor-1 in the stimulated periodontal ligament cells with tumor necrosis factor-α (2014)
  • Author(s): Kawabe M, Ohyama H, Kato-Kogoe N, Yamada N, Yamanegi K, Nishiura H, Hirano H, Kishimoto H, Nakasho K.
  • Journal Title: Med Mol Morphol Volume: 25 Issue: 3 Pages: 54-68
  • DOI: 10.1007/s00795-014-0094-8
  • Peer Reviewed / Open Access