Effect of IL-22 on immune response against periodontal bacteria

• Project/Area Number: 26463151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Osaka Medical College (2016); Hyogo Medical University (2014-2015)
• Principal Investigator: Kato-kogoe Nahoko 大阪医科大学, 医学部, 助教 (60509115)
• Co-Investigator(Kenkyū-buntansha): 大山 秀樹 兵庫医科大学, 医学部, 非常勤講師 (90280685) ; 中山 真彰 岡山大学, 医歯薬学総合研究科, 助教 (10579105) ; 山根木 康嗣 兵庫医科大学, 医学部, 講師 (00434944) ; 山田 直子 兵庫医科大学, 医学部, 講師 (10319858) ; 黒田 義弘 姫路獨協大学, 薬学部, 特別教授 (90093236)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IL-22 / 歯肉上皮細胞 / 細胞内侵入細菌 / ＩＬ－２２ / 歯周病 / P.gingivalis / 歯周病細菌 / 抗菌ペプチド

Outline of Final Research Achievements

This study focused on the effects of IL-22 on the response against periodontal bacteria in gingival epithelial cells. We found that IL-22 reduced gingival epithelial cell differentiation and subsequently decreased antibiotic peptide productivity. In addition, incubation with IL-22 decreased the invasion of Porphyromonas gingivalis into the gingival epithelial cells. The results suggest that IL-22 augments resistance to bacterial invasion of gingival epithelial cells.
The effect of IL-22 on immune response against periodontal bacteria.

Research Products

• [Journal Article] Functional analysis of differences in transcriptional activity conferred by genetic variants in the 5' flanking region of the IL12RB2 gene. (2016)
  • Author(s): Kato-Kogoe N, Ohyama H, Okano S, Yamanegi K, Yamada N, Hata M, Nishiura H, Abiko Y, Terada N, Nakasho K
  • Journal Title: Immunogenetics Volume: 68(1) Issue: 1 Pages: 55-65
  • DOI: 10.1007/s00251-015-0882-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells. (2015)
  • Author(s): Kuroda Y, Kato-Kogoe N, Tasaki E, Yuasa-Sunagawa M, Yamanegi K, Nakasyo K, Nakase I, Futaki S, Tohyama Y, Hirose M
  • Journal Title: European Journal of Pharmacology Volume: 765 Pages: 24-33
  • DOI: 10.1016/j.ejphar.2015.08.004
  • Peer Reviewed
• [Journal Article] Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. (2015)
  • Author(s): Yamanegi K, Kawabe M, Futani H, Nishiura H, Yamada N, Kato-Kogoe N, Kishimoto H, Yoshiya S, Nakasho K.
  • Journal Title: Int J Oncol Volume: 46 Issue: 5 Pages: 1994-2002
  • DOI: 10.3892/ijo.2015.2924
  • Peer Reviewed
• [Journal Article] Expression of interleukin-34 and colony stimulating factor-1 in the stimulated periodontal ligament cells with tumor necrosis factor-α (2014)
  • Author(s): Kawabe M, Ohyama H, Kato-Kogoe N, Yamada N, Yamanegi K, Nishiura H, Hirano H, Kishimoto H, Nakasho K.
  • Journal Title: Med Mol Morphol Volume: 25 Issue: 3 Pages: 54-68
  • DOI: 10.1007/s00795-014-0094-8
  • Peer Reviewed / Open Access
• [Journal Article] Annexin A3 plays a role in cytoplasmic calcium oscillation by extracellular calcium in the human promyelocytic leukaemia HL-60 cells differentiated by phorbol-12-myristate-13-acetate (2014)
  • Author(s): Hiroshi Nishiura, Koji Yamanegi, Mutsuki Kawabe, Nahoko Kato-Kogoe, Naoko Yamada, Keiji Nakasho
  • Journal Title: Experimental and Molecular Pathology Volume: 97 Issue: 2 Pages: 241-246
  • DOI: 10.1016/j.yexmp.2014.07.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant