| Project/Area Number |
26463198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
Ryo Koufuchi 鶴見大学, 歯学部, 講師 (10298268)
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| Co-Investigator(Kenkyū-buntansha) |
井上 裕子 日本薬科大学, 薬学部, 准教授 (50367306)
斎藤 一郎 鶴見大学, 歯学部, 教授 (60147634)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ドライマウス / イソフラボン / 女性ホルモン / エストロゲン / 口腔乾燥症 / 酸化ストレス / シェーグレン症候群 / エクオール / ゲニステイン / ダイゼイン |
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| Outline of Final Research Achievements |
Dry mouth (xerostomia) don’t make enough saliva to keep mouth wet. It is a multi-factorial disease and reduced quality of life (QOL). In addition, the disease has been reported common in menopausal women. This study was conducted to test of equol affect salivary secretion，oxidative stress markers, equol concentrations and subjective measurements.
Nine patients were given equol orally at a dosage of 10mg/day for 1 month, and salivary secretion, oxidative stress markers, equol concentrations in the urine and subjective measurements were analyzed before and after treatment. The results showed a significant improvement based on the equol and self-completed questionnaire. Subjective parameters that improved significantly after treatment score, included discomfort in teeth and mouth, constipation and white hair. The saliva flow rate results are increase after 1 month.
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