Onset mechanisms of atopic dermatitis induced by saturate fatty acid of breast milk
| Project/Area Number |
26500010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Hiroshima University |
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Principal Investigator |
Kanno Masamoto 広島大学, 医歯薬保健学研究院(医), 教授 (40161393)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー疾患 / アトピー性皮膚炎 / 母乳 / 自然免疫系 / 自然リンパ球 / メタボローム解析 / マウス発症モデル / モデルマウス / 脂肪酸 / アレルギー / サイトカイン / IgE / インフラマソーム / 自然免疫 / マウスモデル |
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| Outline of Final Research Achievements |
Breastfeeding is believed to influence the infants’ immune system development and may even affect various immunological responses later in life. A cohort study was carried out to monitor atopic dermatitis(AD) development in breast-fed children. About 10% of the AD+ mothers milk was positive (DAMPs+) when introduced to human cells in vitro. To identify the DAMP molecules, targeted metabolomics analysis was performed. This indicated presence of higher amount of several saturated fatty acids (SFA). In vivo study of HR-1 hairless mice breast-fed on lactating period with high SFA diet showed a higher incidence of skin eczema and AD-like skin symptoms. We are focusing on innate immunity and how SFA promote skin eczema and IgE increase. Among the changes observed in high SFA-milk diet mice include alterations in the intestinal and skin lymphocytes development. We concluded immunological mechanisms and aspect of nutrition based development mechanisms of atopic dermatitis.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Identification of DAMPs molecules in mother’s milk of a cohort study on atopic dermatitis in breastfed infants: Mouse model study and correlation with gut ILCs2016
Author(s)
KANNO, M., Kong, W.-S., Inoue, H., Shimojyo, N., Tsuyama, N., Arita, M., Guo, Y.
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Journal Title
EUROPEAN J. IMMUNOL.
Volume: 46
Issue: S1
Pages: 1-1274
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes.2015
Author(s)
Mokuda S, Miyazaki T, Ito Y, Yamasaki S, Inoue H, Guo Y, Kong WS, Kanno M, Takasugi K, Sugiyama E, Masumoto J.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 9795-9795
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Involvement of ILCs in the pathogenesis of atopic dermatitis mouse model.2016
Author(s)
Kong, W.-S., Inoue, H., Shimojyo, N., Tsuyama, N., Arita, M., Guo, Y.and KANNO, M.,
Organizer
第４５回日本免疫学会学術集会
Place of Presentation
Okinawa convention Center 宜野湾市 沖縄
Year and Date
2016-12-05
Related Report
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[Presentation] Identification of DAMPs molecules in mother’s milk of a cohort study on atopic dermatitis in breastfed infants: Mouse model study and correlation with gut ILCs.2016
Author(s)
KANNO, M., Kong, W.-S., Inoue, H., Shimojyo, N., Tsuyama, N., Arita, M., Guo, Y.
Organizer
Internationa Congress of Immunology (ICI2016)
Place of Presentation
Melbourne Australia
Year and Date
2016-08-20
Related Report
Int'l Joint Research / Invited
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