Does the intake of n-3 fatty acids contribute to infant growth and development -Verification by epidemiology-

• Project/Area Number: 26500016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Kagawa Nutrition University
• Principal Investigator: Kawabata Terue 女子栄養大学, 栄養学部, 教授 (80190932)
• Co-Investigator(Kenkyū-buntansha): 仲井 邦彦 東北大学, 医学系研究科, 教授 (00291336)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: n-3系脂肪酸 / 出生コホート / 母乳 / 血液 / 脂肪酸不飽和化酵素 / スニップ / トランス脂肪酸 / 不飽和脂肪酸代謝酵素

Outline of Final Research Achievements

We examined the relationship between mothers’ fish intakes and n-3 fatty acid metabolism during the lactation period and the growth and development of their infants. The compositions and concentrations of the n-3 fatty acid docosahexaenoic acid (DHA) in maternal milk were significantly positively correlated with the mothers’ fish intakes. The C/C type of the rs174547 SNP in the delta-5 fatty acid desaturase gene was found in 15% of mothers, the DHA composition (wt%) of maternal milk of mothers with the C/C type was significantly lower than that of mothers with the T/T type. When the growth of infants was analyzed according to the DHA concentration ingested from birth to 7 months, no association was found between DHA concentration and the weight gain of infants. We believe that further analysis is required to clarify the relationship between DHA ingestion and growth in infants.

Research Products

• [Journal Article] Polyunsaturated Fatty Acid Levels in Maternal Erythrocytes of Japanese Women during Pregnancy and after Childbirth. (2017)
  • Author(s): Kawabata T, Kagawa Y, Kimura F, Miyazawa T, Saito S, Arima T, Nakai K, Yaegashi N
  • Journal Title: Nutrients Volume: 9 Issue: 3 Pages: 1-10
  • DOI: 10.3390/nu9030245
  • Peer Reviewed / Open Access
• [Journal Article] Determinants of polyunsaturated fatty acid concentrations in erythrocytes of pregnant Japanese women from a birth cohort study: study protocol and baseline findings of an adjunct study of the Japan environment & Children’s study (2017)
  • Author(s): Saito S, Kawabata T, Tatsuta N, Kimura F, Miyazawa T, Mizuno S, Nishigori H, Arima T, Kagawa Y, Yoshimasu K, Tsuno K, Ito Y, Kamijima M, Nakai K, Yaegashi N, Miyagi Study Group of Japan Environment & Children’s Study.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 22 Issue: 1 Pages: 22-22
  • DOI: 10.1186/s12199-017-0636-5
  • NAID: 210000130204
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Nutrigenetics of Japanese Vegetarians with Polymorphism in the Fatty Acid Desaturase (2016)
  • Author(s): Kagawa Y, Nishijima C, Nakayama K, Iwamoto S, Tanaka A, Kamachi K and Kawabata T
  • Journal Title: Journal of Nutrition & Food Sciences Volume: 6 Issue: 03 Pages: 1-15
  • DOI: 10.4172/2155-9600.1000498
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly. (2016)
  • Author(s): Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M, Kontai Y, Horikawa C, Kawashima H, Shibata H, Kagawa Y, Kawabata T.
  • Journal Title: Prostaglandins Leukot Essent Fatty Acids. Volume: 105 Pages: 9-14
  • DOI: 10.1016/j.plefa.2015.11.005
  • Peer Reviewed
• [Journal Article] Nutrigenetics of Japanese Vegetarians with Polymorphism in the Fatty Acid Desaturase. (2016)
  • Author(s): Kagawa Y, Nishijima C, Nakayama K, Iwamoto S, Tanaka A, Kamachi K and Kawabata T.
  • Journal Title: J Nutr Food Sci. Volume: 6 Pages: 1-15
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study (2015)
  • Author(s): Yamazaki I, Kimura F, Nakagawa K, Nakai K, Arima T, Kawabata T, Kagawa Y, Saitoh S, Mizuno S, Yaegashi N, Miyazawa T.
  • Journal Title: Journal of Oleo Science Volume: 64 Issue: 8 Pages: 905-914
  • DOI: 10.5650/jos.ess15071
  • NAID: 130005090062
  • ISSN: 1345-8957, 1347-3352
  • Peer Reviewed / Open Access
• [Presentation] 児の出生体重と母親の体格及び母体血・臍帯血中脂肪酸との関連－エコチル調査の追加調査より－ (2016)
  • Author(s): 松本梓、川端輝江、木村ふみ子、宮澤陽夫、仲井邦彦、瀧田希、有馬隆博、八重樫伸生
  • Organizer: 日本脂質栄養学会第25回大会
  • Place of Presentation: 秋田県
  • Year and Date: 2016-09-16
• [Presentation] 母乳の成分分析を通じた児の栄養摂取状況に関する考察－エコチル調査の追加調査より－ (2016)
  • Author(s): 川端輝江、香川靖雄、鈴木美記子、長田昌士、瀧田希、仲井邦彦
  • Organizer: 日本脂質栄養学会第25回大会
  • Place of Presentation: 秋田県
  • Year and Date: 2016-09-16
• [Presentation] 母乳中のマクロ栄養素組成が児の発育・発達に与える影響‐エコチル調査の追加調査より‐ (2016)
  • Author(s): 鈴木 美記子、豊田 なつ来、木村 有希、 長田 昌士、川端 輝江、香川 靖雄、龍田 希、仲井 邦彦
  • Organizer: 第5回日本DOHaD研究会学術集会
  • Place of Presentation: 東京都
  • Year and Date: 2016-07-24
• [Presentation] 多価不飽和脂肪酸と子どもの成長と発達に関する出生コホート調査プロコル－エコチル調査の追加調査として実施－ (2016)
  • Author(s): 仲井邦彦、瀧田希、鈴木朋恵、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、吉益光一、津野香奈美、伊藤由起、上島通浩、有馬隆博、八重樫伸生
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 兵庫県
  • Year and Date: 2016-05-15
• [Presentation] 妊娠女性の末梢血赤血球多価不飽和脂肪酸の季節性について－エコチル追加調査から－ (2016)
  • Author(s): 鈴木朋恵、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、瀧田希、仲井邦彦
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 兵庫県
  • Year and Date: 2016-05-15
• [Presentation] 母の脂肪酸不飽和化酵素遺伝子多型と母体及び臍帯血中赤血球脂肪酸組成との関係－エコチル調査の追加調査における検討－ (2016)
  • Author(s): 仁田玲子、川端輝江、香川靖雄、中山一大、岩本禎彦、木村ふみ子、宮澤陽夫、仲井邦彦、鈴木朋恵、瀧田希、有馬隆博、八重樫伸生
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 兵庫県
  • Year and Date: 2016-05-15
• [Presentation] 遺伝的背景を踏まえた若年女性の食事と血中脂肪酸組成との関連 (2016)
  • Author(s): 堀口さやか、佐々木秀幸、河島洋、柴田浩志、香川靖雄、川端輝江
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 兵庫県
  • Year and Date: 2016-05-14
• [Presentation] 臍帯血と妊娠期間中及び出産後の母体血間との赤血球脂肪酸組成における関連 (2015)
  • Author(s): 川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、八重樫伸生
  • Organizer: 日本脂質栄養学会第24回大会
  • Place of Presentation: 佐賀県
  • Year and Date: 2015-08-28
• [Presentation] The relation of fatty acid composition among the placenta and erythrocytes of the maternala and fetal blood in Japanese pregnant women (2015)
  • Author(s): Kimura F, Yamazaki I, Nakagawa K, Nakai K, Kawabata T, Kagawa Y, Saitoh S, Mizuno S, Yaegashi N, Arima T, Miyazawa T
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] The relationship between n-3 PUFA intake and exposure to PCB and methylmercury from seafood in a POPs reduction Intervention study (2015)
  • Author(s): Yaginuma K, Kurokawa N, Sasaki Y, Kawabata T, Nakatsuka H, Murata K, Nakai K
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Polyunsaturated fatty acids profile of maternal erythrocytes and its determinants in Japanese pregnant women from an adjunct JECS cohort (2015)
  • Author(s): Nakai K, Saitoh S, Kawabata T, Kimura F, Tatsuta N, Nakagawa K, Miyazawa, T, Arima T, Kagawa Y, Mizuno S, Nishigori H, Yaegashi N
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Influence of a fatty acid desaturase gene polymorphism on blood long-chain polyunsaturated fatty acids: comparison between young and elderly women (2015)
  • Author(s): Horiguchi S, Nakayama K, Iwamoto S, Ishijima A, Minezaki T, Baba M, Kontai Y, Horikawa C, Kawashima H, Shibata H, Kagawa Y, Kawabata T
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yokohama
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] 胎盤組織における長鎖多価不飽和脂肪酸生合成に関わる中間代謝物の解析 (2014)
  • Author(s): 山崎潔大、木村ふみ子、仲川清隆、川端輝江、仲井邦彦、有馬隆博、水野聖士、八重樫伸生、宮澤陽夫
  • Organizer: 日本脂質栄養学会第23回大会
  • Place of Presentation: 東京国際交流館
  • Year and Date: 2014-08-30
• [Presentation] 母体血赤血球中長鎖多価不飽和脂肪酸と生活環境・社会経済的要因について (2014)
  • Author(s): 川端輝江、下田和美、土門茉利奈、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、八重樫伸生
  • Organizer: 日本脂質栄養学会第23回大会
  • Place of Presentation: 東京国際交流館
  • Year and Date: 2014-08-30
• [Presentation] 菜食期間による血中脂肪酸組成の変化についての検討 (2014)
  • Author(s): 西島千陽、仲本桂子、川端輝江、渡邊昌、香川靖雄
  • Organizer: 日本脂質栄養学会第23回大会
  • Place of Presentation: 東京国際交流館
  • Year and Date: 2014-08-29
• [Presentation] 母体血および臍帯血赤血球中脂肪酸組成と非妊娠時BMIとの関連 (2014)
  • Author(s): 下田和美、川端輝江、香川靖雄、木村ふみ子、宮澤陽夫、仲井邦彦、有馬隆博、水野聖士、八重樫伸生
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 札幌市 酪農学園大学
  • Year and Date: 2014-05-30
• [Presentation] 高齢者の血中脂肪酸組成と脂肪酸不飽和化酵素遺伝子多型との関連 (2014)
  • Author(s): 堀口さやか、石島晶子、嶺崎隆幸、馬場真美子、金胎芳子、中山一大、岩本禎彦、香川靖雄、堀川千賀、河島洋、柴田浩志、川端輝江
  • Organizer: 第68回日本栄養・食糧学会大会
  • Place of Presentation: 札幌市 酪農学園大学
  • Year and Date: 2014-05-30