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High resolution 3D imaging with vacuum electrospray droplet ion beams

Research Project

Project/Area Number 26505004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field オミクス計測科学
Research InstitutionUniversity of Yamanashi

Principal Investigator

NINOMIYA Satoshi  山梨大学, 総合研究部, 准教授 (10402976)

Research Collaborator HIRAOKA Kenzo  山梨大学, クリーンエネルギー研究センター, 特命教授 (80107218)
SAKAI Yuji  山梨大学, クリーンエネルギー研究センター, 研究員 (10594103)
CHEN Lee Chuin  山梨大学, 大学院総合研究部, 准教授 (40585577)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords帯電液滴 / 二次イオン質量分析 / イメージング / 深さ方向分析 / イオン銃 / 表面分析
Outline of Final Research Achievements

We developed a technique for producing a stable electrospray of aqueous solution in a vacuum, and designed the prototype of a vacuum-type electrospray droplet ion (V-EDI) gun for surface and interface analysis. The V-EDI gun was connected to a triple-focus time-of-flight analyzer, and the secondary ion yields of some biomolecular samples produced by the V-EDI beams were measured. The secondary ion yields by the V-EDI beams were much enhanced than those by Ga ion beams. In addition, the biomolecular samples were etched by the V-EDI beams with less damage. From those results, the high resolution 3D imaging mass spectrometry could be realized by using the V-EDI beams.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (19 results)

All 2017 2016 2015 2014 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] Secondary Ion Mass Spectrometry Analysis of Renal Cell Carcinoma with Electrospray Droplet Ion Beams2017

    • Author(s)
      Satoshi Ninomiya, Kentaro Yoshimura, Lee Chuin Chen, Sen Takeda, Kenzo Hiraoka
    • Journal Title

      Mass Spectrometry

      Volume: 6 Issue: 1 Pages: A0053-A0053

    • DOI

      10.5702/massspectrometry.A0053

    • NAID

      130005312295

    • ISSN
      2186-5116, 2187-137X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sputtering properties for polyimide by vacuum electrospray droplet impact (V-EDI) using size-selected cluster ions2017

    • Author(s)
      Yuji Sakai, Satoshi Ninomiya, Kenzo Hiraoka
    • Journal Title

      Surface and Interface Analysis

      Volume: 49 Issue: 2 Pages: 127-132

    • DOI

      10.1002/sia.6070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secondary ion yields for vacuum-type electrospray droplet beams measured with a triple focus time-of-flight analyzer2016

    • Author(s)
      Satoshi Ninomiya, Yuji Sakai, Ryo Watanabe, Mauo Sogou, Takuya Miyayama, Daisuke Sakai, Kastumi Watanabe, Lee Chuin Chen, Kenzo Hiraoka
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 30 Issue: 20 Pages: 2279-2284

    • DOI

      10.1002/rcm.7703

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Secondary ions produced by electrospray droplet impact with m/z selection from 103 to 1062016

    • Author(s)
      Satoshi Ninomiya, Lee Chuin Chen, Yuji Sakai, Kenzo Hiraoka
    • Journal Title

      Journal of Vacuum Science and Technology B

      Volume: 34[3] Issue: 3

    • DOI

      10.1116/1.4943024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] XPS depth analysis of metal/polymer multilayer by vacuum electrospray droplet impact2015

    • Author(s)
      Yuji Sakai, Rio Takaishi, Satoshi Ninomiya, Kenzo Hiraoka
    • Journal Title

      Surface and Interface Analysis

      Volume: 47[1] Issue: 1 Pages: 77-81

    • DOI

      10.1002/sia.5669

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a diode laser assisted vacuum-type charged droplet beam source2014

    • Author(s)
      Satoshi Ninomiya, Lee Chuin Chen, Yuji Sakai, Kenzo Hiraoka
    • Journal Title

      Surface and Interface Analysis

      Volume: 46[S1] Issue: S1 Pages: 364-367

    • DOI

      10.1002/sia.5532

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 帯電液滴およびガスクラスター衝撃による二次イオンの測定2017

    • Author(s)
      二宮啓, 十河真生, 坂井大輔, 渡邉勝己, チェンリーチュイン, 平岡賢三
    • Organizer
      2017年<第64回>応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 真空型帯電液滴およびクラスタービームによる二次イオン収率2016

    • Author(s)
      二宮啓, 十河真生, 宮山卓也, 坂井大輔, 渡邉勝己, チェンリーチュイン, 平岡賢三
    • Organizer
      2016年<第77回>応用物理学会秋季学術講演会
    • Place of Presentation
      朱鷺メッセ (新潟県新潟市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Time-of-flight secondary ion mass spectrometry with a vacuum-type electrospray droplet ion gun2016

    • Author(s)
      Satoshi Ninomiya, Yuji Sakai, Mauo Sogou, Takuya Miyayama, Daisuke Sakai, Katsumi Watanabe, Lee Chuin Chen, Kenzo Hiraoka
    • Organizer
      The International Symposium on SIMS and Related Techniques Based on Ion-Solid Interactions (SISS-18)
    • Place of Presentation
      成蹊大学 (東京都武蔵野市)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 真空型帯電液滴ビームによる二次イオン収率増加効果2016

    • Author(s)
      二宮啓, 境悠治, 十河真生, 宮山卓也, 坂井大輔, 渡邉勝己, チェンリーチュイン, 平岡賢三
    • Organizer
      日本学術振興会「マイクロビームアナリシス第141委員会」 第164回研究会
    • Place of Presentation
      株式会社堀場製作所 東京オフィス (東京都千代田区)
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 帯電液滴およびGaビーム衝撃により生成される二次イオンの収率2016

    • Author(s)
      渡邊諒, 二宮啓, 境悠治, チェンリーチュイン, 平岡賢三
    • Organizer
      第64回質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク (大阪府吹田市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 飛行時間型質量分析計に搭載した真空型帯電液滴ビーム銃による二次イオンの測定2016

    • Author(s)
      二宮啓, 境悠治, 十河真生, 宮山卓也, 坂井大輔, 渡邉勝己, チェンリーチュイン, 平岡賢三
    • Organizer
      2016年<第63回>応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学大岡山キャンパス (東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 真空型帯電液滴ビーム銃の開発と表面分析への応用2015

    • Author(s)
      二宮啓, 境悠治, チェン・リーチュイン, 平岡賢三
    • Organizer
      2015年真空・表面科学合同講演会
    • Place of Presentation
      つくば国際会議場 (茨城県つくば市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Secondary ions produced by electrosprayed droplet impacts with m/z selection from 103 to 1062015

    • Author(s)
      Satoshi Ninomiya, Yuji Sakai, Lee Chuin Chen, Kenzo Hiraoka
    • Organizer
      20th International Conference on Secondary Ion Mass Spectrometry
    • Place of Presentation
      The Westin Seattle (Seattle, United States)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 真空エレクトロスプレーにより得られる帯電液滴ビームの特性2015

    • Author(s)
      二宮 啓 境悠治 チェン・リーチュイン 平岡賢三
    • Organizer
      2015年<第62回>応用物理学会春季学術講演会
    • Place of Presentation
      東海大学湘南キャンパス(神奈川県・平塚市)
    • Year and Date
      2015-03-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 真空下エレクトロスプレーにより生成される帯電液滴の質量電荷比分布2014

    • Author(s)
      二宮 啓 境悠治 チェン・リーチュイン 平岡賢三
    • Organizer
      2014年(平成26年)第75回応用物理学会秋季学術講演会
    • Place of Presentation
      北海道大学札幌キャンパス(北海道札幌市)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Research-status Report
  • [Remarks] 山梨大学 研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispDetail.Scholar?fid=0&id=A05372ED879330E5

    • Related Report
      2016 Annual Research Report 2015 Research-status Report 2014 Research-status Report
  • [Remarks] 山梨大学 工学部 研究紹介 新しいイオンビームの開発とその応用に関する研究

    • URL

      http://www.eng.yamanashi.ac.jp/laboratory/sninomiya/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 質量分析・表面分析用の新規イオンビーム銃の研究開発

    • URL

      http://www.ee.yamanashi.ac.jp/sninomiya/

    • Related Report
      2015 Research-status Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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