| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This study aimed to examine the effect of long-term exercise training and physical inactivity on hindlimb unloading-induced muscle atrophy in the rat soleus muscle. Our data reveals that long-term physical inactivity increases the trimethylation of lysine residue 9 of histone H3, whereas regular physical exercise training decreases it in the rat soleus muscle. Although exercise training didn’t completely prevent hindlimb unloading-induced muscle atrophy, the trimethylation of lysine residue 9 of histone H3 and E3 ligase mRNA levels were downregulated by physical exercise training. These observations indicate that physical exercise training partly attenuates hindlimb unloading-induced disuse muscle atrophy in the rat soleus muscle. This might be mediated by downregulation of trimethylation of lysine residue 9 of histone H3 and muscle atrophy-related gene expression.
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