Muscle memory in space environment to be elucidated by epigenetics.
| Project/Area Number |
26506021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
宇宙生命学
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内藤 久士 順天堂大学, スポーツ健康科学研究科, 教授 (70188861)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 微小重力環境 / ヒストン修飾 / 遺伝子発現 / エピジェネティクス / マッスルメモリー / トレーニング / 骨格筋萎縮 / 廃用性筋萎縮 / 運動不足 |
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| Outline of Final Research Achievements |
This study aimed to examine the effect of long-term exercise training and physical inactivity on hindlimb unloading-induced muscle atrophy in the rat soleus muscle. Our data reveals that long-term physical inactivity increases the trimethylation of lysine residue 9 of histone H3, whereas regular physical exercise training decreases it in the rat soleus muscle. Although exercise training didn’t completely prevent hindlimb unloading-induced muscle atrophy, the trimethylation of lysine residue 9 of histone H3 and E3 ligase mRNA levels were downregulated by physical exercise training. These observations indicate that physical exercise training partly attenuates hindlimb unloading-induced disuse muscle atrophy in the rat soleus muscle. This might be mediated by downregulation of trimethylation of lysine residue 9 of histone H3 and muscle atrophy-related gene expression.
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Report
(4 results)
Research Products
(23 results)
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[Presentation] Physical inactivity-induced histone modification in rat soleus muscle.2016
Author(s)
Yoshihara T, Kakigi R, Tsuzuki T, Shuo-wen C, Natsume T, Takamine Y, Ichinoseki-Sekine N, Machida S, Sugiura T, Naito H.
Organizer
The American College of Sports Medicine 63th Annual Meeting
Place of Presentation
Boston, MA, USA
Year and Date
2016-05-31
Related Report
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