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Importance of structure of food proteins on the allergenicity

Research Project

Project/Area Number 26560054
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionKyoto University

Principal Investigator

MARUYAMA NOBUYUKI  京都大学, (連合)農学研究科(研究院), 准教授 (90303908)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords種子 / 貯蔵タンパク質 / 高次構造 / 大豆 / アレルゲン / アレルギー / 食品 / 植物
Outline of Final Research Achievements

There has been an increase in patients who develop food allergies, as well as an increase in patients who exhibit allergy symptoms to plant seeds, which are widely used as food materials. In the present study, we identified structural regions of proteins that are important for allergy symptoms in soybean, a major cause of food allergies, and also found structural features of epitopes involved in allergy symptoms.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] リコンビナント大豆コンポーネントを利用したアレルゲン解析2015

    • Author(s)
      丸山 伸之
    • Journal Title

      日本小児難治喘息アレルギー疾患学会誌

      Volume: 13 Pages: 47-49

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nut allergen components and their molecular structure2015

    • Author(s)
      丸山 伸之
    • Journal Title

      Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology

      Volume: 29 Issue: 3 Pages: 303-311

    • DOI

      10.3388/jspaci.29.303

    • NAID

      130005104355

    • ISSN
      0914-2649, 1882-2738
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食物アレルゲン解析の進歩2014

    • Author(s)
      丸山 伸之
    • Journal Title

      小児科診療

      Volume: 77 Pages: 1249-1253

    • Related Report
      2014 Research-status Report
  • [Journal Article] アレルゲンとコンポーネントの研究の進歩2014

    • Author(s)
      丸山 伸之
    • Journal Title

      医学の歩み

      Volume: 252 Pages: 927-930

    • Related Report
      2014 Research-status Report
  • [Presentation] 植物性食物アレルギーにおけるコンポーネント2015

    • Author(s)
      丸山 伸之
    • Organizer
      第2回日本アレルギー学会総合アレルギー講習会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 診断効率の高い大豆アレルゲンコンポーネントの分子設計に関する検討2015

    • Author(s)
      丸山 伸之, 中川朋子, 伊藤 浩明, 田中 昭, 佐藤 さくら, 海老澤 元宏
    • Organizer
      第64回日本アレルギー学会学術大会 ミニシンポジウム
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都・品川区)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳幼児の重症大豆アレルギーにおけるGly m 5, Gly m 6, Gly m 8, Gly m 4特異IgE抗体2014

    • Author(s)
      柴田瑠美子, 村上 洋子, 小田嶋 博, 丸山 伸之
    • Organizer
      第19回 日本ラテックスアレルギー研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Gly m 5, Gly m 6, Gly m 8 and Gly m 4 specific IgE antibodies in the sera of Japanese children with anaphylaxis caused by fermentaed and processed soybean2014

    • Author(s)
      Shibata R, Murakami Y, Odajima H, Maruyama, N.
    • Organizer
      European Academy of Allergy and Clinical Immunology Congress 2014
    • Place of Presentation
      Copenhagen
    • Year and Date
      2014-06-08
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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