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Analysis of inhibitory mechanisms of polyphenols on bacterial induced food poisoning and dermatitis

Research Project

Project/Area Number 26560061
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

SHIMAMURA YUKO  静岡県立大学, 食品栄養科学部, 助教 (60452025)

Co-Investigator(Renkei-kenkyūsha) MASUDA SHUICHI  静岡県立大学, 食品栄養科学部, 准教授 (40336657)
YANAGIDA AKIO  東京薬科大学, 薬学部, 教授 (40318192)
NAKAYAMA TSUTOMU  日本獣医生命科学大学, 応用生命科学部, 教授 (50150199)
ITO SOHEI  静岡県立大学, 食品栄養科学部, 准教授 (70372836)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords黄色ブドウ球菌 / ブドウ球菌エンテロトキシンA / ポリフェノール / カテキン / 遺伝子伝播
Outline of Final Research Achievements

The mechanism of interaction between staphylococcal enterotoxin A (SEA) and polyphenols and inhibitory effect on them SEA toxin activity was examined. As a result, apple proanthocyanidins (AP) and (-)-epigallocatechin gallate (EGCG) inhibited the binding affinity of the anti-peptide antibodies to SEA active sites. AP and EGCG inactivated the cell proliferation and IFN-γ production induced by SEA in spleen cells. In addition, some polyphenols inhibited the biofilm formation and biofilm-related gene (icaD) expression. These polyphenols inhibited SEA gene transfer from SEA producing strains to SEA non-producing strains. In further experiments, the influence of interaction between SEA and polyphenols on toxin activity expression, and inhibitory mechanisms on the SEA gene transfer will be clarified.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (24 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Plant-derived polyphenols interact with staphylococcal enterotoxin A and inhibit toxin activity.2016

    • Author(s)
      Shimamura Y, Aoki N, Sugiyama Y, Tanaka T, Murata M, Masuda S.
    • Journal Title

      PLOS ONE

      Volume: 11(6) Issue: 6 Pages: e0157082-e0157082

    • DOI

      10.1371/journal.pone.0157082

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Formation of glycidol fatty acid esters in meat samples cooked byvarious methods2016

    • Author(s)
      Inagaki R., Hirai C., Shimamura Y., Masuda S.
    • Journal Title

      Journal of Food Processing and Tecnology

      Volume: 7 Issue: 02 Pages: 1-6

    • DOI

      10.4172/2157-7110.1000557

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cloning of Phenylalanine Ammonia-lyase and its Role in Enzymatic Browning of Mung Bean Sprout during Cold Storage2016

    • Author(s)
      Sameshima N, Nishimura M, Murakami K., Kogo Y, Shimamura Y, Sakuta M, Murata M.
    • Journal Title

      Food Science and Technology Research

      Volume: 22 Issue: 2 Pages: 255-260

    • DOI

      10.3136/fstr.22.255

    • NAID

      130005147054

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The application of alkaline and acidic electrolyzed water in the sterilization of chicken breasts and beef liver2015

    • Author(s)
      Shimamura Y., Shinke M., Hiraishi M., Tsuchiya Y., Masuda S.:
    • Journal Title

      Food Science and Nutrition

      Volume: 4 Issue: 3 Pages: 431-440

    • DOI

      10.1002/fsn3.305

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Screening of tea extract and theaflavins for inhibitory effects on the biological activity and production of staphylococcal enterotoxin A.2014

    • Author(s)
      Shimamura Y., Aoki N, Sugiyama Y., Nakayama T., Masuda S.
    • Journal Title

      J. Food Sci.

      Volume: 79(11) Issue: 11

    • DOI

      10.1111/1750-3841.12566

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of the phenolic compounds contributing to antibacterial activity in ethanol extracts of Brazilian red propolis.2014

    • Author(s)
      Inui S, Hatano A, Yoshino M, Hosoya T, Shimamura Y, Masuda S, Ahn MR, Tazawa S, Araki Y, and Kumazawa S
    • Journal Title

      Nat. Prod. Res.

      Volume: Epub ahead of print Issue: 16 Pages: 1-4

    • DOI

      10.1080/14786419.2014.898146

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 黄色ブドウ球菌の毒素活性に対するカテキン類の制御機構の解明2017

    • Author(s)
      内海 未央,平井 央子,島村 裕子,伊藤 圭祐,石井 剛志,増田 修一
    • Organizer
      第71回日本栄養・食糧学会大会
    • Place of Presentation
      沖縄
    • Year and Date
      2017-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibitory effect of catechins on toxin activity of staphylococcal enterotoxin A2016

    • Author(s)
      Mio Utsumi, Chikako Hirai, Yuko Shimamura, Shuichi Masuda
    • Organizer
      The 3nd International Conference on Pharma and Food
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ブドウ球菌エンテロトキシンAの毒素活性に対するカテキン類の阻害効果の比較2016

    • Author(s)
      内海 未央,平井 央子,島村 裕子,増田 修一
    • Organizer
      第13回 日本カテキン学会年次学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 食肉中における各種食中毒菌の付着・侵入および増殖に対する液体塩こうじの抑制効果2016

    • Author(s)
      島村 裕子,江川 瑞規,平田 伸行,松原 英祐,増田 修一
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] ブドウ球菌毒素エンテロトキシンA遺伝子の伝播機序の解明2016

    • Author(s)
      折原 杏奈,尾崎 順哉,島村 裕子,三好 規之,増田 修一
    • Organizer
      第71回日本栄養・食糧学会中部支部大会
    • Place of Presentation
      岐阜
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリフェノール類による毒素型食中毒抑制メカニズムの解明2016

    • Author(s)
      島村 裕子
    • Organizer
      (公財) 日本農芸化学会中部支部第178回例会若手シンポジウム
    • Place of Presentation
      静岡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 食中毒菌の制御におけるポリフェノールおよび電解水の利用2015

    • Author(s)
      島村 裕子,平井 央子,中野 祥吾,伊藤 創平,青野 博志,篠田 和代,増田 修一
    • Organizer
      静岡食品環境フォーラム
    • Place of Presentation
      静岡
    • Year and Date
      2015-12-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 食中毒菌の毒素活性に対するEGCGとその誘導体の抑制効果および作用機序の解明2015

    • Author(s)
      平井 央子,島村 裕子, 杉山 由華, 増田 修一
    • Organizer
      第12回日本カテキン学会年次学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 茶カテキン類による黄色ブドウ球菌の毒素遺伝子伝播抑制メカニズムの解明2015

    • Author(s)
      尾崎 順哉,島村 裕子, 柴田 昌治, 増田 修一
    • Organizer
      第12回日本カテキン学会年次学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 食中毒菌の毒素産生および活性に対する緑茶ポリフェノール類の抑制効果2015

    • Author(s)
      島村 裕子
    • Organizer
      第12回日本カテキン学会年次学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2015-12-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Plant-derived polyphenols inhibit toxin activities of staphylococcal enterotoxin A2015

    • Author(s)
      Chikako Hirai, Yuko Shimamura, Yuka Sugiyama, Shuichi Masuda
    • Organizer
      The 20th shizuoka forum on health and longevity
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食中毒菌の食肉内部への侵入や病原性因子発現に影響を与える因子の解明2015

    • Author(s)
      江川 瑞規,島村 裕子,土屋 祐介,篠田 和代,青野 博志,増田 修一
    • Organizer
      日本農芸化学会中部支部・関西支部合同大会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] The mechanism inhibitory effect of plant-derived polyphenols on staphylococcal enterotoxin A activities2015

    • Author(s)
      Chikako Hirai, Yuko Shimamura, Yuka Sugiyama, Shuichi Masuda
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食中毒菌の毒素産生および活性に対するEGCGの抑制効果とその作用機序の解明2014

    • Author(s)
      平井央子,島村裕子, 杉山由華, 増田修一
    • Organizer
      第11回日本カテキン学会年次学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] カテキン類による抗菌活性とブドウ球菌毒素遺伝子伝播の抑制効果の関係2014

    • Author(s)
      尾崎順哉,島村裕子, 柴田昌治, 増田修一
    • Organizer
      第11回日本カテキン学会年次学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of novel control method for preventing food-poisoning using food additives derived from polyphenols.2014

    • Author(s)
      Chikako Hirai, Yuko Shimamura, Yuka Sugiyama, Shuichi Masuda
    • Organizer
      The 2nd International Conference on Pharma and Food
    • Place of Presentation
      Shizuoka, Japan
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] ブドウ球菌毒素遺伝子の伝播機序の解明および伝播抑制成分の探索2014

    • Author(s)
      尾崎順哉,島村裕子, 柴田昌治, 増田修一
    • Organizer
      日本食品科学工学会第61回大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 食中毒菌の毒素産生および活性に対するポリフェノール系既存食品添加物の抑制効果2014

    • Author(s)
      平井央子,島村裕子, 杉山由華, 増田修一
    • Organizer
      日本食品科学工学会第61回大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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