Crosstalk between inflammation and the basic mechanisms of skeletal muscle hypertrophy or atrophy

• Project/Area Number: 26560289
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Suzuka University of Medical Science
• Principal Investigator: Sasai Nobuaki 鈴鹿医療科学大学, 保健衛生学部, 准教授 (20454762)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 理学療法 / 骨格筋 / 萎縮 / 肥大 / 炎症反応 / 酸化ストレス

Outline of Final Research Achievements

The aim of this study is to elucidate the association of inflammation with basic mechanisms which induce skeletal muscle hypertrophy or atrophy. Although many suggestions on the association are there, clarifications of actual mechanisms are still incomplete.
In this term, we used mouse muscle hypertrophy and atrophy models, and cell culture models. These models were well established. In mice models, however, no significant difference was showed in the macrophage-detection as the main observation. Further observations on those models must contribute to the elucidations.