| Project/Area Number |
26640057
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
TAMURA Atsushi 大阪大学, 生命機能研究科, 准教授 (00362525)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | タイトジャンクション / クローディン / 微小環境 / 電流 / 膜電位 / 上皮細胞 |
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| Outline of Final Research Achievements |
The effects of ion or water permeability through epithelial tight junction is not well understood.
In this research, the aim is to clarify the biological functions and it's mechanisms regulated directly or indirectly by the properties of intercellular tight junction in epithelial cells.One of the most interesting biological function is pH dependency, especially dependency of lower pH of basal side culture medium on TER. It suggests there is some special mechanism which works as a sensor residing only in basal side of cells.
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