Can short-lived African medaka be a model of neuropsychiatric disease ?

Research Project

Project/Area Number	26640061
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Laboratory animal science
Research Institution	University of Miyazaki
Principal Investigator	Matsui Hideaki 宮崎大学, 医学部, 助教 (60710853)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords	アフリカメダカ / 神経科学 / 神経変性疾患
Outline of Final Research Achievements	In this research project, we found that Africa medaka (short-lived vertebrate) showed Parkinson-like pathology in age-dependent manner. This phenotype was not caused by genetic manipulation or toxin exposure but by aging. This medaka showed neurodegeneration and progression of alpha-synuclein pathology in older stage. This phenotype is very similar to human Parkinson disease phenotype.

Report

(3 results)