| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Outline of Final Research Achievements |
Vertebrates have three principal body axes; Anterior-Posterior (A-P), Dorsal-Ventral (D-V), and Left-Right (L-R) axis. In many organisms, A-P axis is the first overt body one, establishment of A-P axis is based on early molecular asymmetry and essential for later development, including the formation of other axes.The origin of the DVE is pushed back at least to the peri-implantation stage, which is much earlier than expected.
In this research, I revealed that Nodal and Lefty1 was expressed in uterus in implantation stage. These results can be guessed that A-P asymmetries is induced maternal Nodal signaling.
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