Molecular mechanisms of heat acclimation - How to prevent heat stroke
| Project/Area Number |
26650173
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied anthropology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIDO Osamu 島根大学, 医学部, 教授 (40175386)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 暑熱順化 / 熱中症 / 温度センサー / 水チャネル / 神経新生 |
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| Outline of Final Research Achievements |
Recently, temperature of earth is increasing and heat stroke often occurs. To prevent heat stroke in the world, molecular mechanisms of heat adaptation should be revealed. In this study, we investigated the effects of heat on cells.
Heat increased heat shock proteins and aquaporins. Heat also induced tolerance of hypoxia. Interestingly, heat down-regulated TRPV1, a thermal sensor. Here, we revealed a port of molecular mechanism of heat acclimation.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells2014
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
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Journal Title
Cell biochemistry and biophysics
Volume: (in press)
Issue: 1
Pages: 301-7
DOI
Related Report
Peer Reviewed
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