Research Project
Grant-in-Aid for Challenging Exploratory Research
In general, zinc deficiency is diagnosed by evaluation of serum zinc status. However, serum zinc status is altered by daily fluctuation or during inflammation, which may be a problem in the case that the accurate diagnosis is required for elderly people because they often suffer from various chronic diseases. Because, at present, Japan faces super-aged society at present, establishing the new strategy for accurate diagnosis of zinc deficiency is more important than ever.In this study, I tried to establish such strategy by generating useful monoclonal antibody to detect proteins/enzymes whose expression is changed in response to zinc status. Moreover, I investigated zinc requiring enzyme activity whose activity was changed during zinc deficiency. I generated one antibody, which nicely detects zinc transporter in zinc-deficient dependent pattern, and one enzyme whose activity shows drastic change in response to zinc deficiency.
All 2016 2015 2014
All Journal Article (22 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 19 results, Open Access: 12 results, Acknowledgement Compliant: 10 results) Presentation (19 results) (of which Int'l Joint Research: 2 results, Invited: 16 results) Book (1 results)
Pediatr Res
Volume: 印刷中
120006863495
Arch Biochem Biophys
Volume: ー Pages: 37-42
10.1016/j.abb.2016.03.035
Int J Mol Sci.
Volume: 17 Issue: 3 Pages: 1-22
10.3390/ijms17030336
120005947123
Am J Physiol Regul Integr Comp Physiol
Volume: 310 Issue: 5 Pages: R459-R468
10.1152/ajpregu.00439.2015
亜鉛栄養治療
40021096575
Biochem Biophys Res Commun.
Volume: 471 Issue: 1 Pages: 109-116
10.1016/j.bbrc.2016.01.171
Journal of Nutritional Science and Vitaminology
Volume: 61 Issue: Supplement Pages: S44-S46
10.3177/jnsv.61.S44
130005109853
Volume: 61 Issue: Supplement Pages: S116-S118
10.3177/jnsv.61.S116
130005109877
Biochemical Journal
Volume: 472 Issue: 2 Pages: 183-193
10.1042/bj20150862
120006305978
Genes Nutr.
Volume: 10 Issue: 5 Pages: 487-487
10.1007/s12263-015-0487-x
Physiol Rev.
Volume: 95 Pages: 749-84
細胞工学
Volume: 34 Pages: 310-316
Analytical Sciences
Volume: 31 Issue: 2 Pages: 85-89
10.2116/analsci.31.85
130004827460
Cell Signal
Volume: 27 Issue: 3 Pages: 470-478
10.1016/j.cellsig.2014.12.001
J Neurosci Res
Volume: 93(2) Issue: 2 Pages: 370-9
10.1002/jnr.23491
120007100194
EMBO Molecular Medicine
Volume: 6 Issue: 8 Pages: 1028-1042
10.15252/emmm.201303809
Methods Enzymol
Volume: 534 Pages: 77-92
120005359197
日本応用酵素協会誌
Volume: 49 Pages: 9-15
ビタミン
Volume: 88 Pages: 560-564
生体の科学
Volume: 65 Pages: 370-378
40020183766
Functional Food
Volume: 25 Pages: 48-51
Cellular and Molecular Life Sciences
Volume: 71 Issue: 17 Pages: 3281-3295
10.1007/s00018-014-1617-0