| Project/Area Number |
26670178
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIMI Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
SATO Noriyuki 札幌医科大学, 医学部, 名誉教授 (50158937)
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| Research Collaborator |
KAWATA Koji
KAMEKURA Rhyuta
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 濾胞ヘルパーT細胞 / 免疫組織化学 / 免疫病理学 / 病理診断学 / 免疫関連疾患 / 濾胞ヘルパーT細胞サブセット / ナイーブヘルパーT細胞 / 病理組織診断 / リンパ腫 / 炎症性疾患 / 制御性B細胞 / 血液 / 免疫アレルギー疾患 / アレルギー性鼻炎 / 気管支喘息 / 病理診断 |
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| Outline of Final Research Achievements |
In this study, we performed functional analysis of T follicular helper (Tfh) cells and their transitional cell subsets to apply novel findings for histopathological examinations of immune-related disorders. As a result, we found high expression of a Bob1 transcription factor in Tfh cells and the involvement of Bob1 in the regulation of cell numbers of Tfh cells (Eur J Immunol. 2016). Further, we revealed that Tfh2-cell polarization preferentially occurred in the patients with allergic asthma and allergic rhinitis, as seen as Th2-cell polarization in the patients（Clin Immunol. 2015）. This implies the common mechanism underlying Tfh2-cell and Th2-cell polarization, suggesting that a manner of skewing of Tfh-cell subset would reflect a disease-specific feature of helper CD4(+) T cells. By virtue of a characteristic molecule(s) in Tfh cells and Tfh-cell subsets, further studies might lead to a new modality for histopathological diagnosis of immune-related disorders.
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