Study of lipopeptide-specific immunity against AIDS: from monkeys to humans
| Project/Area Number |
26670483
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAORI Akifumi 京都大学, 医学研究科, 教授 (20324626)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞・組織 / ウイルス / 免疫学 / 脂質 / エイズ / リポペプチド |
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| Outline of Final Research Achievements |
Immune responses directed against viral "peptides" have been studied extensively, which have medical implications, including the development of peptide vaccines. This study focussed on immune responses directed against viral "lipopeptides", and it was elucidated how this new immune pathway was activated. This study has provided an important basis for the near-future identification of such an immune pathway in humans.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.2015
Author(s)
Morita D, Yamamoto Y, Mizutani T, Ishikawa T, Suzuki J, Igarashi T, Mori N, Shiina T, Inoko H, Fujita H, Iwai K, Tanaka Y, Mikami B, Sugita M,
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Journal Title
Nat Commun.
Volume: 7
Issue: 1
Pages: 10356-10356
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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