Study of Kawasaki Disease
Project/Area Number |
26670489
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大谷 克城 旭川医科大学, 医学部, 准教授 (90396367)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 血管炎 / コレクチン |
Outline of Final Research Achievements |
Kawasaki disease generally develops due to microbe infection and is a disease characterized by intense inflammation of the blood vessel in the whole body. Applicants focused on CL-P1 and went the inspection of the hypothesis to bring about sustained blood vessel inflammation in this study. Firstly, they chose CL-P1 as a candidate to bind CRP and evaluated the activation of the complement to on this occasion that an ascent of sudden CRP was generated when some infection and inflammation happened. They showed that CRP trapped by CL-P1 draws C1q, and activates a classical pathway at this place. Furthermore, it was revealed that this reaction activates the alternative pathway. These results suggest the possibility of exercised new complement activation mechanism through CRP.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Three pentraxins C-reactive protein, serum amyloid p component and pentraxin 3 mediate complement activation using Collectin CL-P12017
Author(s)
2.Roy, N., Ohtani, K., Hidaka, Y., Amano, Y., Matsuda, Y., Mori, K., Hwang, I., Inoue, N., Wakamiya, N.
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Journal Title
Biochim Biophys Acta
Volume: 861
Issue: 2
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Collectin CL-P1 utilizes C-reactive protein for complement activation.2016
Author(s)
5.Roy, N., Ohtani, K., Matsuda, Y., Mori, K., Hwang, I., Suzuki, Y., Inoue, N., Wakamiya, N.
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Journal Title
Biochim Biophys Acta
Volume: 1860
Issue: 6
Pages: 1118-1128
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome2015
Author(s)
Venkatraman Girija U, Furze CM, Gingras AR, Yoshizaki T, Ohtani K, Marshall JE, Wallis AK, Schwaeble WJ, El-Mezgueldi M, Mitchell DA, Moody PC, Wakamiya N, Wallis R
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Journal Title
BMC Biol
Volume: 13
Issue: 1
Pages: 27-27
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis2015
Author(s)
Troegeler A, Lugo-Villarino G, Hansen S, Rasolofo V, Henriksen ML, Mori K, Ohtani K, Duval C, Mercier I, Bénard A, Nigou J, Hudrisier D, Wakamiya N, Neyrolles O
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Journal Title
PLoS One
Volume: 10
Issue: 7
Pages: e0132692-e0132692
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Molecular basis of sugar recognition by collectin-K1 and the defects caused by mutations associated with 3MC syndrome .2015
Author(s)
Umakhanth Venkatraman Girija, Christopher Furze, Alexandre Gingras, Takayuki Yoshizaki, Katsuki Ohtani, Jamie Marshall, Wilhelm Schwaeble, Mohammed El-Mezgueldi, Daniel Mitchell, Peter Moody, Nobutaka Wakamiya, and Russell Wallis.
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Journal Title
BMC biology
Volume: 13
Pages: 27-27
Related Report
Peer Reviewed
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[Presentation] Establishment of the comprehensive complement examination system for complement-related diseases by the Japanese association for complement research.2016
Author(s)
Yoshihiko Hidaka, Norimitsu Inoue, Yasufumi Ohtsuka, Toshihiro Sawai, Toshiyuki Miyata, Isao Osawa, Hidechika Okada, Tarou Kinoshita, Hideharu Sekine, Minoru Takahashi, Hiroshi Tsukamoto, Miki Nakao, Masaru Nonaka, Misao Matsushita, Tetsurou Yamamoto, Takahiko Horiuchi, Nobutaka Wakamiya
Organizer
26th International Complement Workshop
Place of Presentation
Kanazawa (Japan)
Year and Date
2016-09-04
Related Report
Int'l Joint Research
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