Prevention of autism by drug therapy targeting mTOR system in developing brain
| Project/Area Number |
26670491
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIZUGUCHI Masashi 東京大学, 大学院医学系研究科(医学部), 教授 (20209753)
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| Co-Investigator(Kenkyū-buntansha) |
池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 自閉症 / 結節性硬化症 / モデル動物 / 行動解析 / mTOR系 / 橋渡し研究 |
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| Outline of Final Research Achievements |
Many patients with tuberous sclerosis complex (TSC), a hereditary disorder caused by an excessive activation of the mTOR system, have autism. As a translational research to develop drug therapy of autism, we conducted an experimental study using mouse models of TSC. When TSC mice were given an mTOR inhibitor, rapamycin, their autistic symptom, namely impairment of reciprocal social action, improved. The effect was comparable between adolescent and adult animals. On the other hand, animals who underwent chronic rapamycin treatment during the developmental period showed marked adverse effects, such as deterioration of systemic condition and atrophy of organs. The optimal dose and duration of drug therapy remained to be determined.
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Report
(4 results)
Research Products
(31 results)
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[Presentation] West症候群/Rett症候群の原因遺伝子CDKL5は、グルタミン受容体局在を制御し記憶/情動/易痙攣性を調節する2015
Author(s)
田中輝幸, 奥田耕助, 小林静香, 深谷昌弘, 高雄啓三, 渡邉紀, 村上拓冬, 萩原舞, 阪上洋行, 水口雅, 宮川剛, 真鍋俊也.
Organizer
第38回日本小児遺伝学会学術集会
Place of Presentation
パシフィコ横浜（横浜）
Year and Date
2015-07-25
Related Report
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[Presentation] 多形膠芽腫を合併した結節性硬化症の１例2014
Author(s)
高橋長久, 太田さやか, 下田木の実, 水野葉子, 岩崎博之, 三牧正和, 武笠晃丈, 斎藤真木子, 水口雅
Organizer
第2回日本結節性硬化症学会学術総会
Place of Presentation
東京大学（東京都）
Year and Date
2014-11-15
Related Report
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