Changes of intestinal microbiome of preterm labor cases and endometriosis cases by metagenome analysis.
| Project/Area Number |
26670717
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
SAITO Shigeru 富山大学, 大学院医学薬学研究部(医学), 教授 (30175351)
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| Co-Investigator(Kenkyū-buntansha) |
山田 拓司 東京工業大学, 生命理工学院, 准教授 (10437262)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腸内細菌叢 / 早産 / 子宮内膜症 / 炎症性疾患 / 産科学 / 生殖医学 |
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| Outline of Final Research Achievements |
Preterm delivery and endometriosis are classified to inflammatory diseases. Recent data demonstrate that the changes of intestinal flora are correlated with inflammatory diseases by affecting immune system. Therefore, we have studied the metagenome profile in preterm labor cases and endometriosis cases. We have not found significant changes in intestinal flora, but abundance of Escherichia/Shigella was found in some preterm labor cases, and abundance of Meganonas and decreased Parabacteroides were found in some endometriosis cases. We should clarified the relationship between patients conditions and abnormality of intestinal flora.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System2016
Author(s)
Yoneda S, Shiozaki A, Yoneda N, Ito M, Shima T, Fukuda K, Ueno T, Niimi H, Kitajima I, Kigawa M, Saito S
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Journal Title
American Journal of Reproductive Immunology
Volume: 75(4)
Issue: 4
Pages: 440-50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Impairment of the accumulation of decidual T cells, NK cells, and monocytes, and the poor vascular remodeling of spiral arteries, were observed in oocyte donation cases, regardless of the presence or absence of preeclampsia.2016
Author(s)
Nakabayashi Y, Nakashima A, Yoshino O, Shima T, Shiozaki A, Adachi T, Nakabayashi M, Okai T, Kushima M, Saito S
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Journal Title
J Reprod Immunol.
Volume: 114
Pages: 65-74
DOI
Related Report
Peer Reviewed
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[Journal Article] Polymicrobial Amniotic Fluid Infection with Mycoplasma/Ureaplasma and Other Bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor2015
Author(s)
Yoneda N, Yoneda S, Niimi H, Ueno T, Hayashi S, Ito M, Shiozaki A, Urushiyama D, Hata K, Suda W, Hattori M, Kigawa M, Kitajima I, Saito S.
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Journal Title
American Journal of Reproductive Immunology
Volume: 75(2)
Issue: 2
Pages: 112-25
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Melting temperature mapping method: A novel method for identification of unknown pathogenic microorganisms within three hours of sample of collection.2015
Author(s)
Niimi H, Ueno T, Hayashi S, Abe A, Tsurue T, Mori M, Tabata H, Minami H, Goto M, Akiyama M, Yamamoto Y, Saito S, Kitajima I
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Journal Title
Scientific Reports.
Volume: 5
Issue: 1
Pages: 12543-12543
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Multiple pregnancy,short cervix, part-time worker, steroid use, low educational level, and male fetus are risk factors for preterm birth in Japan: A multicenter, prospective study.2014
Author(s)
Shiozaki, A., Yoneda S., Nakabayashi M., Takeda Y., Takeda S., Sugimura M., Yoshida K., Tajima A., Manabe M., Akagi K., Nakagawa S., Tada K., Imafuku N., Ogawa M., Mizunoe T., Kanayama N., Itoh H., Minoura S., Ogino M., Saito S.
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Journal Title
J Obstet Gynaecol Res.
Volume: 40
Issue: 1
Pages: 53-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Compilation of copy number variants identified in phenotypically normal and parous Japanese women2014
Author(s)
Migita O, Maehara K, Kamura H, Miyakoshi K, Tanaka M, Morokuma S, Fukushima K, Shimamoto T, Saito S, Sago H, Nishihama K, Abe K, Nakabayashi K, Umezawa A, Okamura K, Hata K
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Journal Title
J. Hum. Genet.
Volume: 59
Issue: 6
Pages: 326-331
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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