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Potential therapy with artificial HDL and photoresponsive nanomaterial for Age-related maculopathy

Research Project

Project/Area Number 26670754
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKyoto University

Principal Investigator

GOTOH Norimoto  京都大学, 医学(系)研究科(研究院), 准教授 (20632095)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Tatsuya  京都大学, 学内共同利用施設等, 准教授 (90410737)
KOTANI Kazuhiko  自治医科大学, 医学部, 教授 (60335510)
TSUJIKAWA Akitaka  香川大学, 医学部, 教授 (40402846)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords眼科学 / 加齢黄斑変性 / HDL / 遺伝子発現 / ドラッグデリバリーシステム / 眼科 / ドラッグデリバリー / ナノ材料 / 次世代シークエンス
Outline of Final Research Achievements

(1) Establishing RNA expression profile of human choroidal neovascularization samples using next generation sequencing. (2) Developing novel transcorneal drug delivery system of artificial HDL delivery into the mouse retina. (3) Establishing modified method for evaluating HDL cholesterol efflux with small clinical samples.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Presentation (1 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] 脈絡膜新生血管抜去検体の網羅的遺伝子発現解析2015

    • Author(s)
      後藤謙元、飯田慶、山城健児、長谷川智子、万代道子、鈴間潔、山田亮、松田文彦、吉村長久
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 高密度リポタンパク質およびその細胞親和性ペプチドを融合した高密度リポタンパク質の点眼による後眼部薬物デリバリー2014

    • Inventor(s)
      須田謙史、村上達也、吉村長久、後藤謙元
    • Industrial Property Rights Holder
      須田謙史、村上達也、吉村長久、後藤謙元
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-16
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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