Preparation of bone regeneration material by using porous and strong chitin nanofiber composite
Project/Area Number |
26708026
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Polymer/Textile materials
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Research Institution | Tottori University |
Principal Investigator |
Shinsuke Ifuku 鳥取大学, 工学(系)研究科(研究院), 准教授 (70402980)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
|
Keywords | ナノ材料 / バイオマス / 生体材料 / キチン / ナノファイバー / 骨再生材料 / キトサン / ハイドロゲル |
Outline of Final Research Achievements |
We have succeeded in preparing for the chitin nanofibers from crab shell. The chitin nanofiber has 10 nm in diameter, efficient mechanical properties, and variety of biological properties. In this study, a calcium phosphate/chitin nanofiber composite material was prepared for bone tissue engineering. Chitin nanofiber offered a useful template with which to form calcium phosphate crys-tal as with the biomineralization of crab shell in nature. Calcium phosphate improved the mechanical properties of the hydrogel. This unique inorganic/organic nanocomposite modeled on nature is expected to expand the application of chitin nanofibers in medical and dental fields by utiliz-ing their morphological, mechanical, and biological properties.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] Oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fulorouracil-induced intestinal mucositis in mice2017
Author(s)
Ryo Koizumi, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Kosuke Ochi Takeshi Tsuka, Tomohiro Imagawa, Tomohiro Osaki, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku
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Journal Title
Oral administration of surface-deacetylated chitin nanofibers and chitosan inhibit 5-fulorouracil-induced intestinal mucositis in mice
Volume: 18
Issue: 2
Pages: 279-279
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats2017
Author(s)
Makoto Anraku, Ryo Tabuchi, Shinsuke Ifuku, Tomone Nagae, Daisuke Iohara, Hisao Tomida, Kaneto Uekama, Toru Maruyama, Shigeyuki Miyamura, Fumitoshi Hirayama, Masaki Otagiri
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Journal Title
Carbohydrate Polymers
Volume: 161
Pages: 21-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Biomaterials based on freeze dried surface-deacetylated chitin nanofibers reinforced with sulfobutyl ether b-cyclodextrin gel in wound dressing application2016
Author(s)
Ryo Tabuchi, Kazuo Azuma, Ryotaro Izumi, Tsubasa Tanou, Yoshiharu Okamoto, Tomone Nagae, Daisuke Iohara, Kaneto Uekama, Masaki Otagiri Fumitoshi Hirayama, Shinsuke Ifuku, Makoto Anraku
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Journal Title
International Journal of Pharmaceutics
Volume: 511
Issue: 2
Pages: 1080-1087
DOI
Related Report
Peer Reviewed
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[Journal Article] Chitin nanofibrils suppress skin inflammation in atopic dermatitis-like skin lesions in NC/Nga mice2016
Author(s)
Ryotaro Izumi, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Masaaki, Nagashima, Tomohiro Osaki, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku
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Journal Title
Carbohydrate Polymers
Volume: 146
Pages: 320-327
DOI
Related Report
Peer Reviewed
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[Journal Article] Protective effect of chitin urocanate nanofibers against ultraviolet radiation2015
Author(s)
Ikuko Ito, Toshikazu Yoneda, Yoshihiko Omura, Tomohiro Osaki*, Shinsuke Ifuku, Hiroyuki Saimoto, Kazuo Azuma, Tomohiro Imagawa, Takeshi Tsuka, Yusuke Murahata, Norihiko Ito, Yoshiharu Okamoto, Saburo Minami
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Journal Title
Marine Drugs
Volume: 13
Issue: 12
Pages: 7463-7475
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of chitosan nanofiber sheets for antifungal application2015
Author(s)
Egusa, M., Iwamoto, R., Izawa, H., Morimoto, M., Saimoto, H., Kaminaka, H. and Ifuku, S.
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Journal Title
Int. J. Mol. Sci.
Volume: 16
Issue: 11
Pages: 26202-26210
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of oral administration of chitin nanofiber on plasma metabolites and gut microorganisms2015
Author(s)
Kazuo Azuma, Ryotaro Izumi, Mari Kawata, Tomone Nagae, Tomohiri, Osaki, Yusuke Murahata, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Ito, Yoshiharu Okamoto, Minoru Morimoto, Hironori Izawa, Hiroyuki Saimoto, Shinsuke Ifuku
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Journal Title
International Journal of Molecular Sciences
Volume: 16
Issue: 9
Pages: 21931-21949
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of surface-deacetylated chitin nanofibers in an experimental model of hypercholesterolemia2015
Author(s)
K. Azuma, T. Nagae, T. Nagai, H. Izawa, M. Morimoto, Y. Murahata, T. Osaki, T. Tsuka, T. Imagawa, N. Ito, Y. Okamoto, H. Saimoto, S. Ifuku
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Journal Title
International Journal of Molecular Sciences
Volume: 16
Issue: 8
Pages: 17445-17455
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bioactive gyroid scaffolds formed by sacrificial templating of nanocellulose and nanochitin hydrogels as instructive platforms for biomimetic tissue engineering2015
Author(s)
Jose Guillermo, Torres-Rendon, Tim Femmer, Laura De Laporte, Thomas Tigges, Khosrow Rahimi, Felix Gremse, Sara Zafarnia, Wiltrud Lederle, Shinsuke Ifuku, Matthias Wessling, John G. Hardy, Andreas Walther
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Journal Title
Advanded Materials
Volume: -
Issue: 19
Pages: 2989-2995
DOI
Related Report
Peer Reviewed
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[Journal Article] Favorable effects of superficially deacetylated chitin nanofibrils on the wound healing process2015
Author(s)
Ryotaro Izumi, Shuntaro Komada, Kosuke Ochi, Lisa Karasawa, Tomohiro Osaki, Yusuke Murahata, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Itoh, Yoshiharu Okamoto, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Kazuo Azuma,Shinsuke Ifuku
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Journal Title
Carbohydrate Polymers
Volume: 123
Pages: 461-467
DOI
Related Report
Peer Reviewed
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[Journal Article] Biological adhesive based on carboxymethyl chitin derivatives and chitin nanofibers2015
Author(s)
Kazuo Azuma, Masahiro Nishihara, Haruki Shimizu, Yoshiki Ito, Osamu Takashima, Tomohiro Osaki, Norihiko Ito, Tomohiro Imagawa, Yusuke Murahata, Takeshi Tsuka, Hironori Izawa, Shinsuke Ifuku, Saburo Minami, Hiroyuki Saimoto, Yoshiharu Okamoto, Minoru Morimoto
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Journal Title
Biomaterials
Volume: 42
Pages: 20-29
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Favorable effects of superficially deacetylated chitin nanofibrils on thewound healing process2015
Author(s)
Ryotaro Izumia, Shuntaro Komadab, Kosuke Ochi, Lisa Karasawa, Tomohiro Osaki, Yusuke Murahata, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Itoh,Yoshiharu Okamoto, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Kazuo Azuma, Shinsuke Ifuku
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Journal Title
Carbohydrate Polymers
Volume: 123
Pages: 461-467
Related Report
Peer Reviewed
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