| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
Tumor microenvironment plays an important role in cancer growth and metastasis. The applicant has so far found and reported that cancer cells remaining under nutrient deprivation under hypoxia promote malignant transformation and resistance to cancer treatments. This study elucidated the mechanism of malignant transformation of cancer induced by hypoxia and nutrient starvation from detailed analysis of cancer stem cells, and a novel cancer control method targeting cancer stem cells resistant to hypoxia and nutrient starvation. Research was aimed to development of novel anti-cancer strategy, we elucidated malignant transformation mechanisms caused by tumor microenvironments such as hypoxia, nutrient starvation and acidic pH, and a new target that can be expected to have a synergistic effect in combination with existing chemotherapy and angiogenesis inhibition therapy for molecular basis of and therapeutic application.
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