• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Dissecting the mechanism of tissue growth to adjust time-dependent morphogenesis

Research Project

Project/Area Number 26711013
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Developmental biology
Research InstitutionKyoto University

Principal Investigator

Ohsawa Shizue  京都大学, 生命科学研究科, 准教授 (80515065)

Research Collaborator Igaki Tatsushi  京都大学, 大学院生命科学研究科, 教授 (00467648)
Akai Nanami  神戸大学, 大学院医学研究科, 大学院生
Wada Yayoi  京都大学, 大学院生命科学研究科, 大学院生
Inui Yukiko  京都大学, 大学院生命科学研究科, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords組織成長 / 細胞ターンオーバー / 成長遅延 / ショウジョウバエ / 細胞間相互作用 / 細胞競合 / Wingless
Outline of Final Research Achievements

Although issue growth is coordinated along the developmental time scale in animals, the molecular basis remains elusive. We examined the mechanism by which tissue growth is coordinated in animals that causes developmental delay, by using a series of Drosophila mutant that have a mutation in gene encoding ribosomal protein, Minute. Minute show significant delay in the progression of their larval period, but importantly they develop to almost normal adult flies. We found that developmental delay cooperate with upregulation of Wingless expression in wing discs, which trigger “cell-turnover” and the following normal wing morphogenesis during development.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (26 results)

All 2017 2016 2015 2014 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 6 results,  Open Access: 1 results) Presentation (18 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition.2017

    • Author(s)
      Masatoshi Yamamoto (#), Shizue Ohsawa (#), Kei Kunimasa, Tatsushi Igaki (#equal contribution)
    • Journal Title

      Nature

      Volume: 542 Issue: 7640 Pages: 246-250

    • DOI

      10.1038/nature21033

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Predator-prey interactions at the interface between two groups of cells in monolayer tissue.2016

    • Author(s)
      Seiya Nishikawa,Atsuko Takamatsu, Shizue Ohsawa, Tatsushi Igaki
    • Journal Title

      J. Theor. Biol.

      Volume: 404 Pages: 40-50

    • DOI

      10.1016/j.jtbi.2016.05.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] JNK signaling is coverted from anti- to pro-tumor pathway by Ras-mediated switch of Warts activity2015

    • Author(s)
      Masato Enomoto, Daisuke Kizawa, Shizue Ohsawa, Tatsushi Igaki
    • Journal Title

      Developmental Biology

      Volume: 403 Issue: 2 Pages: 162-171

    • DOI

      10.1016/j.ydbio.2015.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila2014

    • Author(s)
      Nakamura M, Ohsawa S, Igaki T
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 5264-5264

    • DOI

      10.1038/ncomms6264

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila2014

    • Author(s)
      Takino K, Ohsawa S, Igaki T
    • Journal Title

      Developmental Biology

      Volume: 395 Issue: 1 Pages: 19-28

    • DOI

      10.1016/j.ydbio.2014.09.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dissecting tumor heterogeneity in flies: genetic basis of interclonal oncogenic coorperation2014

    • Author(s)
      Ohsawa S,Takemoto D, Igaki T
    • Journal Title

      J. Biochem

      Volume: 156 Issue: 3 Pages: 129-36

    • DOI

      10.1093/jb/mvu045

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Epithelial cell-turnover ensures morphogenetic robustness in Drosophila2017

    • Author(s)
      Shizue Ohsawa, Nanami Akai, Tatsushi Igaki
    • Organizer
      Joint Meeting of the German and Japanese Societies of Developmental Biologist(口頭発表)
    • Place of Presentation
      Kiel (Germary)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Epithelial cell-turnover ensures morphogenetic robustness in Drosophila2016

    • Author(s)
      Shizue Ohsawa, Megumi Nakayama, Tatsushi Igaki
    • Organizer
      Japan-Austria joint meeting “Understanding the logic behind developmental dynamics"(口頭発表)
    • Place of Presentation
      IST (Austria)
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ロバストな形態形成を支える「細胞ターンオーバー」の遺伝学的解析2016

    • Author(s)
      乾 由希子、大澤 志津江、井垣 達吏
    • Organizer
      第68回日本細胞生物学会・第11回日本ケミカルバイオロジー学会 合同大会(ポスター発表)
    • Place of Presentation
      京都テルサ(京都)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ensuring robust control of organ size by "cell-turnover" in Drosophila2016

    • Author(s)
      Shizue Ohsawa, Nanami Akai, Tatsushi Igaki
    • Organizer
      the CDB Symposium 2016 - Size in Development: Growth, Shape and Allometry -(ポスター発表)
    • Place of Presentation
      理研CDB (神戸)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 発生ロバストネスを支える細胞競合の分子機構2015

    • Author(s)
      大澤 志津江、赤井 菜々美、井垣 達吏
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会 合同大会 ワークショップ(口頭発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] HIppo経路を介した発生ロバストネス機構の遺伝学的解析2015

    • Author(s)
      和田弥生、大澤志津江、井垣 達吏
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会 合同大会 ワークショップ(口頭発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 上皮の恒常性維持を司る細胞競合の分子基盤2015

    • Author(s)
      大澤志津江
    • Organizer
      第1006回生物科学セミナー(口頭発表)
    • Place of Presentation
      東京大学
    • Year and Date
      2015-01-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cell competition that regulates epithelial homeostasis in Drosophila2014

    • Author(s)
      Ohsawa S, Kunimasa K, Yamamoto M, Igaki T
    • Organizer
      MBI-Japan Joint Symposium on Mechanobiology of Development and Multicellular Dynamics(口頭発表)
    • Place of Presentation
      National University of Singapore(シンガポール)
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tissue growth regulation by “cell turnover” in Drosophila2014

    • Author(s)
      Akai N, Ohsawa S, Igaki T
    • Organizer
      MBI-Japan Joint Symposium on Mechanobiology of Deveopment and Multicellular Dynamics (口頭発表)
    • Place of Presentation
      National University of Singapore(シンガポール)
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞間コミュニケーションを介した上皮の恒常性維持2014

    • Author(s)
      大澤志津江
    • Organizer
      南紀生物セミナー(口頭発表)
    • Place of Presentation
      和歌山医科大学(和歌山)
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] エンドサイトーシス制御破綻が引き起こすアポトーシス誘導性増殖の分子基盤2014

    • Author(s)
      瀧野 恭子、大澤 志津江、井垣 達吏
    • Organizer
      第23回日本Cell death学会学術集会(ポスター発表)
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞老化による細胞死耐性獲得と細胞非自律的な腫瘍悪性化2014

    • Author(s)
      中村 麻衣、大澤 志津江、井垣 達吏
    • Organizer
      第23回日本Cell death学会学術集会(ポスター発表)
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 上皮細胞競合を駆動する細胞認識機構の遺伝学的解析2014

    • Author(s)
      大澤 志津江、國政 啓、井垣 達吏
    • Organizer
      第66回日本細胞生物学会大会(口頭発表)
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞老化が駆動する非自律的な腫瘍悪性化の遺伝学的解析2014

    • Author(s)
      中村 麻衣、大澤 志津 江、井垣 達吏
    • Organizer
      第66回日本細胞生物学会大会(口頭発表)
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] エンドサイトーシス制御破綻が駆動する細胞非自律的な増殖制御機構2014

    • Author(s)
      瀧野 恭子、大澤 志津江、井垣 達吏
    • Organizer
      第66回日本細胞生物学会大会(口頭発表)
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Year and Date
      2014-06-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-cell autonomous tumor progression driven by cellular senescence2014

    • Author(s)
      Nakamura M, Ohsawa S, Igaki T
    • Organizer
      第11回日本ショウジョウバエ研究会 (ポスター発表)
    • Place of Presentation
      金沢歌劇座(石川)
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-autonomous tissue growth by endocytic regulation of Eiger and Ras signaling2014

    • Author(s)
      Takino K, Ohsawa S, Igaki T
    • Organizer
      第11回日本ショウジョウバエ研究会(口頭発表)
    • Place of Presentation
      金沢歌劇座(石川)
    • Year and Date
      2014-06-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dissecting the mechanism of cell competition that regulates epithelial homeostasis in Drosophila2014

    • Author(s)
      Ohsawa S, Kunimasa K, Igaki T
    • Organizer
      第47回日本発生生物学会大会(口頭発表)
    • Place of Presentation
      ウインク愛知(名古屋)
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Book] New Principles in Developmental Processes “Cell competition: the struggle for existence in multicellular communities”2014

    • Author(s)
      Kunimasa K, Ohsawa S, Igaki T
    • Total Pages
      13
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Remarks] 京都大学大学院生命科学研究科システム機能学/薬学研究科生理活性制御学HP

    • URL

      http://www.lif.kyoto-u.ac.jp/genetics/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi