| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
Recent advanced single-cell studies increasingly reveals large variations in gene expressions or cellular phenotypes at individual cell level even in an isogenic population. However, a challenge is to develop systematic approaches to address the mechanisms to generate such cellular heterogeneities or to detect the physiological differences between individual cells. Using horizontal gene transfer between prokaryotic cells as a model, we here developed a genome-wide approach to analyze gene expression profiles between subpopulations in a clonal population, and uncovered specific cellular physiology and gene expressions in a particular cell fraction.
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