| Budget Amount *help |
¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
Mammalian oocytes mature in the ovary and ovulation occurs during the metaphase II stage, when the oocytes can be fertilized. It was recently reported that meiotic maturation is interrupted by factors such as aging, which hinders fertilization. To elucidate the reason why meiotic maturation stops in oocytes, in this study, we identified the key functional factor controlling meiotic maturation, and clarified that the proline isomerization enzyme Pin1 is indispensable for the progress of meiotic maturation. This information would help in the production of high-quality oocytes.
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